Browsing by Author "Karakaya, Muharrem"

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    5-Fluorouracyl added infusion fluid in patients with recurrent rhegmatogeneous retinal detachment
    (ELSEVIER SCIENCE BV, 2019-01-01) Karakaya, Muharrem; Albayrak, Sinan; Pehlivanoglu, Seren; Ozkaya, Abdullah; Gocgil, Nur Acar
    Purpose: To compare the efficacy of 5-fluorouracil (5-FU) added the infusion fluid with a control group in the event of grade C PVR in recurrent retinal detachment (RD). Methods: The records of the patients with recurrent retinal detachment with grade C PVR who underwent vitrectomy for retinal detachment surgery between April 2003 and October 2004 were reviewed retrospectively for this comparative study. The recurrent retinal detachment patients with grade C PVR who underwent vitrectomy and had a minimum post-operative follow-up period of 12 months were included. The patients were divided into two groups as study and control groups. 5-FU (200 microgram/ml) and low-molecular-weight-heparin (LMWH) (5 IU/ml) was added into the infusion solution of the study group. Primary outcome measure of this study was the single operation anatomical success at month 12. Results: A total of 43 eyes of 43 patients were included. The control group was consisted of 26 eyes (60.5\%) and the 5-FU group was consisted of 17 eyes (39.5\%). At month 12, single operation anatomical success was obtained in 14 of the 26 patients (53.8\%) in the control group and in 16 of the 17 patients (94.1\%) in the 5-FU group (p = 0.005). Conclusion: Favorable outcomes were obtained in the patients with recurrent RD and grade C PVR in whom 5-FU and LMWH added infusion fluid which was used during vitrectomy.
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    The assessment of autofluorescence of the crystalline lens in diabetic patients and healthy controls: can it be used as a screening test?
    (DOVE MEDICAL PRESS LTD, 2018-01-01) Pehlivanoglu, Seren; Acar, Nur; Albayrak, Sinan; Karakaya, Muharrem; Ofluoglu, Ali
    Background: Our purpose was to demonstrate if measuring lens autofluorescence (AF) with a scanning confocal biomicroscope may be used to identify subjects with undiagnosed type II diabetes mellitus (DM), and hence, for it to be used as a marker for the severity of diabetic retinopathy in diabetic patients. Patients and methods: In this cross-sectional, comparative study, lens AF was measured with scanning confocal lens fluorescence biomicroscope in diabetic and healthy groups. Full ophthalmological examination was performed. Blood tests of fasting plasma glucose, and glycosylated hemoglobin were also analyzed. The correlation between lens AF results and blood tests was evaluated in both groups. The cutoff value for the diagnosis of DM using lens AF was investigated. Results: The study included 191 subjects with a mean age of 52.09 +/- 6.75 years. One hundred and seven (56.0\%) subjects were female, and 84 (44.0\%) were male. Eighty-two (42.9\%) patients had type II DM, and 109 (57.1\%) subjects self-reported as normal. The fluorescence ratio (FR) values ranged from 0.09 to 0.46 (0.23 +/- 0.06) in the total group. Mean FR measurements of diabetic subjects were significantly higher (0.27 +/- 0.06) than those without DM (0.20 +/- 0.05), (p=0.001). A statistically significant correlation was found between glycosylated hemoglobin, fasting plasma glucose, and FR. The cutoff point for the FR according to the presence of DM was found to be 0.24 and above (p=0.001), with a sensitivity of 71.95\% and a specificity of 80.73\%. Conclusion: Measuring AF of human lens as an indirect evidence of increased advanced glycaton end products may helpful in detecting impaired glucose metabolism. Our results show highly significant correlation between possibility of DM and FR.