Browsing by Author "Ozdemir, Hakan"

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Protective effect of pomegranate juice on retinal oxidative stress in streptozotocin-induced diabetic rats
    (IJO PRESS, 2017-01-01) Tugcu, Betul; Nacaroglu, Senay Asik; Gedikbasi, Asuman; Uhri, Mehmet; Acar, Nur; Ozdemir, Hakan
    AIM: To investigate the effect of pomegranate juice (PJ) intake on overall oxidation status in retinas of diabetic rats. METHODS: Twenty-seven rats were divided into four groups as control (CO), diabetic (DM), control treated with PJ (CO-PJ), and diabetic treated with PJ (DM-PJ). The retina tissues were used to determine 8-hydroxy2 `-deoxyguanosine (8OHdG), malondialdehyde (MDA), reduced glutathione (GSH) levels, and the enzyme activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). RESULTS: The levels of 8OHdG and MDA were significantly increased in the retina of DM group compared to CO group (P= 0.001, P< 0.001 respectively). Both 8OHdG and MDA levels were decreased in PJ-DM group compared to DM group (P= 0.004, P< 0.001 respectively). The activities of antioxidant enzymes GSH, SOD, and GDH-Px were significantly decreased in the retina of DM group compared to CO group (P= 0.01). GSH and GSH-Px activities were higher in PJ-DM group compared with DM group (P= 0.010, P= 0.042, respectively) but SOD activity was not statistically different (P= 0.938). CONCLUSION: PJ intake is found to be effective in decreasing oxidative end products, and in increasing the activities of antioxidant enzymes in diabetic retinas of rats, which suggests it may be effective against oxidative stress in diabetic retinas.
  • Thumbnail Image
    Item
    Residents' views about family medicine specialty education in Turkey
    (BMC, 2010-01-01) Uzuner, Arzu; Topsever, Pinar; Unluoglu, Ilhami; Caylan, Ayse; Dagdeviren, Nezih; Uncu, Yesim; Mazicioglu, Mumtaz; Ozcakir, Alis; Ozdemir, Hakan; Ersoy, Fusun
    Background: Residents are one of the key stakeholders of specialty training. The Turkish Board of Family Medicine wanted to pursue a realistic and structured approach in the design of the specialty training programme. This approach required the development of a needs-based core curriculum built on evidence obtained from residents about their needs for specialty training and their needs in the current infrastructure. The aim of this study was to obtain evidence on residents' opinions and views about Family Medicine specialty training. Methods: This is a descriptive, cross-sectional study. The board prepared a questionnaire to investigate residents' views about some aspects of the education programme such as duration and content, to assess the residents' learning needs as well as their need for a training infrastructure. The questionnaire was distributed to the Family Medicine Departments (n = 27) and to the coordinators of Family Medicine residency programmes in state hospitals (n = 11) by e-mail and by personal contact. Results: A total of 191 questionnaires were returned. The female/male ratio was 58.6\%/41.4\%. Nine state hospitals and 10 university departments participated in the study. The response rate was 29\%. Forty-five percent of the participants proposed over three years for the residency duration with either extensions of the standard rotation periods in pediatrics and internal medicine or reductions in general surgery. Residents expressed the need for extra rotations (dermatology 61.8\%