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0 How COVID-19 pandemic affected the psychiatry training of medical students in Turkey? What have we done and what can be done?
(ELSEVIER ESPANA SLU, 2021-01-01) Sancak, B.; Agirbas, U. Ozer; Yavuz, B.
3D and 4D Printing of Polymers for Tissue Engineering Applications
(FRONTIERS MEDIA SA, 2019-01-01) Tamay, Dilara Goksu; Usal, Tugba Dursun; Alagoz, Ayse Selcen; Yucel, Deniz; Hasirci, Nesrin; Hasirci, Vasif
Three-dimensional (3D) and Four-dimensional (4D) printing emerged as the next generation of fabrication techniques, spanning across various research areas, such as engineering, chemistry, biology, computer science, and materials science. Three-dimensional printing enables the fabrication of complex forms with high precision, through a layer-by-layer addition of different materials. Use of intelligent materials which change shape or color, produce an electrical current, become bioactive, or perform an intended function in response to an external stimulus, paves the way for the production of dynamic 3D structures, which is now called 4D printing. 3D and 4D printing techniques have great potential in the production of scaffolds to be applied in tissue engineering, especially in constructing patient specific scaffolds. Furthermore, physical and chemical guidance cues can be printed with these methods to improve the extent and rate of targeted tissue regeneration. This review presents a comprehensive survey of 3D and 4D printing methods, and the advantage of their use in tissue regeneration over other scaffold production approaches.
3D Automated Breast Ultrasound System: Comparison of Interpretation Time of Senior Versus Junior Radiologist
(AVES, 2019-01-01) Arslan, Aydan; Ertas, Gokhan; Aribal, Erkin
Objective: This study aimed to compare the automated breast ultrasound system (ABUS) reading time of breast radiologist to a radiology resident independent of the clinical outcomes. Materials and Methods: One hundred women who underwent screening ABUS between July and August 2017 were reviewed retrospectively. Each study was examined sequentially by a breast radiologist who has more than 20 years of experience in breast radiology and third year resident who has 6 months of experience in breast radiology. Data were analyzed with Spearman' correlation, Wilcoxon Signed Ranks Test and Kruskal-Wallis Test and was recorded. Results: The mean age of patients was 42.02 +/- 11.423 years (age range16-66). The average time for senior radiologist was 223.36 +/- 84.334 seconds (min 118 max 500 seconds). The average time for junior radiologist was 269.48 +/- 82.895 seconds (min 150 max 628 seconds). There was a significant difference between the mean time of two radiologists (p=0.00001). There was a significant difference regarding the decrease in the reading time throughout study with the increase of number of cases read by the breast radiologist (p<0.05)
4H-Pyran-4-one derivatives:
(SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK, 2009-01-01) Us, Demet; Gurdal, Ece; Berk, Barkin; Oktem, Sinem; Kocagoz, Tanil; Caglayan, Berrak; Kurnaz, Isil Aksan; Erol, Dilek Demir
A series of 3-hydroxy-6-methyl-2-((4-substitutedpiperazin-1-yl)methyl)-4H-pyran-4-on e structured compounds were synthesized by reacting 5-hydroxy-2-methyl-4H-pyran-4-one with suitable piperazine derivatives using Mannich reaction conditions. Antibacterial activities of the compounds for E. coli, S. paratyphi, S. flexneri, E. gergoviae, and M. smegmatis were assessed in vitro by using broth dilution for determination of the minimum inhibitory concentration (MIC). In addition, their inhibitory effects over DNA gyrase enzyme were evaluated using a DNA gyrase supercoiling assay. Among the synthesized compounds
5-Fluorouracyl added infusion fluid in patients with recurrent rhegmatogeneous retinal detachment
(ELSEVIER SCIENCE BV, 2019-01-01) Karakaya, Muharrem; Albayrak, Sinan; Pehlivanoglu, Seren; Ozkaya, Abdullah; Gocgil, Nur Acar
Purpose: To compare the efficacy of 5-fluorouracil (5-FU) added the infusion fluid with a control group in the event of grade C PVR in recurrent retinal detachment (RD). Methods: The records of the patients with recurrent retinal detachment with grade C PVR who underwent vitrectomy for retinal detachment surgery between April 2003 and October 2004 were reviewed retrospectively for this comparative study. The recurrent retinal detachment patients with grade C PVR who underwent vitrectomy and had a minimum post-operative follow-up period of 12 months were included. The patients were divided into two groups as study and control groups. 5-FU (200 microgram/ml) and low-molecular-weight-heparin (LMWH) (5 IU/ml) was added into the infusion solution of the study group. Primary outcome measure of this study was the single operation anatomical success at month 12. Results: A total of 43 eyes of 43 patients were included. The control group was consisted of 26 eyes (60.5\%) and the 5-FU group was consisted of 17 eyes (39.5\%). At month 12, single operation anatomical success was obtained in 14 of the 26 patients (53.8\%) in the control group and in 16 of the 17 patients (94.1\%) in the 5-FU group (p = 0.005). Conclusion: Favorable outcomes were obtained in the patients with recurrent RD and grade C PVR in whom 5-FU and LMWH added infusion fluid which was used during vitrectomy.
5-Hydroxyuracil Incision Activity Varies According to the Histological Grade of Non-muscle-invasive Bladder Cancer
(GALENOS YAYINCILIK, 2021-01-01) Keskin, Selcuk; Antmen, Fatma Merve; Somuncu, Berna; Saglican, Yesim; Doganca, Tunkut; Obek, Can; Ince, Umit; Kural, Ali Riza; Muftuoglu, Meltem
Objective: High levels of endonuclease III-like 1 (NTHL1) DNA glycosylase, which plays a role in the first step of the base excision repair pathway, has been related to cancer initiation and progression. 5-hydroxyuracil (5-OHU) oxidative base damage is a substrate for NTHL1 and endonuclease VIII-like 1 enzyme 1 (NEIL1) DNA glycosylases. This study investigates the association of 5-OHU incision activity with the risk of disease progression in patients with non-muscle-invasive bladder cancer (NMIBC) regarding grade and stage. Materials and Methods: During transurethral resection of 17 NMIBC patients, the papillary tumour before monopolar resection and healthy bladder mucosal tissue from the same person were obtained using cold cup biopsy. Both the normal mucosa and NMIBC tumour were pathologically confirmed. The histological grade and stage were also determined. The 5-OHU incision activity of all tissues was measured using a radiolabelled 5-OHU modified base containing DNA substrate. Results: 5-OHU incision activity was significantly higher in all high-grade NMIBC tissue extracts compared with the corresponding normal tissues (p=0.001). However, we found no significant difference in 5-OHU incision activity in low-grade NMIBC tissues (p=0.89). There was also a significant increase in 5-OHU incision activity at the Ta/T1 stage compared with the corresponding normal tissue (p=0.001). Conclusion: The increase in 5-OHU incision activity according to the histological grade of NMIBC tissue indicates that this activity (mainly performed by NTHL1 and NEIL1 DNA glycosylases) might play a role in NMIBC prognosis. Thus, it could be used as a potential prognostic biomarker for NMIBC.
786T/c endothelial nitric oxide synthase gene polymorphism and coronary collateral circulation
(POLISH ACAD SCIENCES, INST IMMUNOL \& EXP THERAPY, 2016-01-01) Seckin, Satilmis; Emrah, Bozbeyoglu; Biyik, Ismail; Emre, Arugaslan; Burak, Tangurek; Azmi, Sungur; Omer, Celik; Sinan, Dagdelen
Introduction: In this study, we investigated the association between -786T/C polymorphism of the endothelial nitric oxide (NOS3) gene in which thymidine is replaced by a cytosine at nucleotide -786 (rs 2070744) and coronary collateral circulation (CCC) in patients with stable coronary artery disease. Materials \& Methods: 286 patients having a critical stenosis (> 95\%) in at least one major epicardial coronary vessel were included in the study. CCC was defined according to the Rentrop classification (R). Patients with R0-1 CCC were included in the poor CCC group and subjects with R2-3 CCC were assigned to the good CCC group. The polymerase chain reaction method was used for genotyping. 152 patients with poor CCC and 134 patients with good CCC were examined. Results: The frequency of cytosine-cytosine (CC) and thymidine-cytosine (TC) genotypes and allele C were higher in the poor CCC group, but the difference did not reach statistical significance. In the dominant model, the frequency of CC+TC vs. thymidine-thymidine (TT) genotypes was significantly higher in the poor CCC group (67.1\% vs. 54.5\%, respectively
A Biomechanical Comparison of Tendon Repair with a Knotless Barbed Suture and a Conventional Monofilament Suture Material: An ex-vivo Animal Experiment
(GALENOS YAYINCILIK, 2020-01-01) Gemalmaz, Halil Can
Objective: Our aim is to compare the ultimate tensile strength and stiffness of a 2/0 barbed suture and a 3/0 polypropylene monofilament suture in a porcine tendon repair model. Methods: Sixteen porcine Achilles tendons were transected and separated into two groups. In group I tendons were repaired with a modified knotless four-strand Kessler technique using a 2/0 V-Loc barbed suture. In group II tendons were repaired with a four-strand Kessler technique using a 3/0 monofilament conventional suture and knots were tied. All specimens were biomechanically tested for ultimate tensile strength (UTS) and stiffness. Mode of failure was also noted. Results: Five specimens in group I failed by stripping of the suture from the tendon tissue, three failed due to suture breakage. In group II two out of eight tendons failed by stripping of the suture and remaining six failed by suture breakage. Median UTS value was found to be 85.96 N (range: 63.24) in group I and 64.29 N (range: 56.84) in group II. Median stiffness value of the samples in group I was found to be 5.67 N/mm (range: 4.32) and in group II it was found to be 4.53 N/mm (range: 6.23). The statistical analysis of UTS and stiffness values revealed no significant difference between the groups (p=0.17 and p=0.56 respectively). Conclusion: A knotless Kessler tendon repair made with a 2/0 barbed suture is biomechanically equivalent to a knotted Kessler tendon repair made with a 3/0 conventional polypropylene suture in ex-vivo conditions.
A biosensor platform based on amine functionalized conjugated benzenediamine-benzodithiophene polymer for testosterone analysis
(WILEY, 2020-01-01) Bulut, Umut; Sanli, Serdar; Cevher, Sevki Can; Cirpan, Ali; Donmez, Sude; Timur, Suna
A novel benzenediamine-benzodithiophene polymer is synthesized for use in biosensor fabrication for the detection of testosterone. The sensory platform is constructed via drop coating on a screen-printed carbon electrode, using poly(benzenediamine-Bis{[}(2-ethylhexyl)oxy]benzodithiophene) (pBDBT) as the polymer layer. Testosterone antibodies are immobilized on the polymer-coated electrode surface via glutaraldehyde, which binds to the surface through the amino functional groups on the polymer backbone. The changes in the surface features due to testosterone binding are investigated via electrochemical techniques such as differential pulse voltammetry, cyclic voltammetry, and electrochemical impedance spectrometry as well as contact angle measurements. Surface morphology of the modified electrodes is characterized by atomic force microscopy. The linear range and limit of detection of the sensor are calculated. Impact of possible interfering compounds is investigated. Furthermore, the sensory platform is utilized for testosterone analysis in synthetic biological fluids.
A Case of Burkitt's Lymphoma Mimicking Peritonitis Carcinomatosa
(GALENOS YAYINCILIK, 2020-01-01) Buyuktas, Deram; Ornek, Serdar; Tecimer, Tulay; Ferhanoglu, Burhan
A Case of Cutaneous Diffuse Large B-cell Lymphoma
(GALENOS YAYINCILIK, 2014-01-01) Cetin, Bulent; Ozet, Ahmet; Orhan, Bulent; Tecimer, Tulay
A Case of Eccrine Porocarcinoma Accompanying Renal Cell Carcinoma
(GALENOS YAYINCILIK, 2021-01-01) Mansur, Ayse Tulin; Karsiyakali, Nejdet; Demirci, Gulsen Tukenmez; Koseoglu, Hikmet; Akman, Yavuz; Yildiz, Semsi
In this case report, we present the coexistence of eccrine porocarcinoma (EPC) and renal cell carcinoma (RCC) in a 69-year-old male patient whose surgical resection pathology of the skin lesion in the right gluteal region was reported as EPC and concurrent radical nephrectomy pathology of the right renal mass was reported as RCC.
A case of elephantiasis nostras verrucosa treated successfully by a new type of compressive garment
(WILEY, 2020-01-01) Mansur, A. Tulin; Ozker, Emre; Demirci, Gulsen Tukenmez
Elephantiasis nostras verrucosa (ENV) is a clinical manifestation composed of hyperkeratotic, verrucous, and papillomatous lesions and dermal fibrosis, which complicate chronic lymphedema. There is currently no cure for ENV, however, several measures have been used to reduce lymphedema and the resultant pseudoepidermal hyperplasia. Supportive dressings and compression therapy still constitute an important part of the treatment. In this report, we present a 69-year-old male patient with ENV developed due to chronic lymphedema caused by venous insufficiency. After failure of healing with conventional two- and three-layered bandages, and elastic stockings, he was successfully treated by a new type of compression garment. We recommend this user friendly garment for prevention of frictional trauma, contact dermatitis, and secondary infection, which all may complicate compression treatments.
A case of pulmonary alveolar microlithiasis associated with a homozygous 195 kb deletion encompassing the entire SLC34A2 gene
(WILEY, 2016-01-01) Stokman, Lara; Nossent, Esther J.; Grunberg, Katrien; Meijboom, Lilian; Yakicier, Mustafa C.; Voorhoeve, Els; Houweling, Arjan C.
Key Clinical Message With around 500 cases published worldwide, pulmonary alveolar microlithiasis is a rare disorder with an autosomal recessive pattern of inheritance. We show for the first time that homozygous deletions encompassing the entire SCL34A2 can be associated with this rare genetic pulmonary disease.
A case of radial arteriovenous fistula during coronary angiography
(TURKISH SOC CARDIOLOGY, 2013-01-01) Gorgulu, Sevket; Norgaz, Tugrul; Sahingoz, Yusuf
A Case of Unclassified Renal Cell Carcinoma Initially Considered as Translocation RCC and Review of Literature
(GALENOS YAYINCILIK, 2021-01-01) Karsiyakali, Nejdet; Ozgen, Mahir Bulent; Ozveren, Bora; Ekici, Isin Dogan; Turkeri, Levent
This case report aimed to review the literature on translocation renal cell carcinoma (tRCC), which is a rare form of kidney cancer and was the initial diagnosis of a recently treated patient. We report our findings in a 30-year-old female who underwent robot-assisted radical nephrectomy for an incidental right renal mass, which was reported as unclassified RCC at final pathologic evaluation after eliminating tRCC as differential diagnosis, and discuss the main aspects of tRCC based on current literature.
A Case Report of Syringocystadenoma Papilliferum Mimicking Basal Cell Carcinoma on the Face
(GALENOS YAYINCILIK, 2012-01-01) Sezer, Engin; Erkek, Emel; Sahin, Sedef
Syringocystadenoma papilliferum is clinically characterized by verrucous nodules or plaques, mainly observed on the scalp during childhood. Histopathologically, epidermal invagination showing luminal epithelial cells with decapitation secretion is diagnostic. Herein, we describe an unusual late-onset case of syringocystadenoma papilliferum mimicking basal cell carcinoma on the face.
A Case with Cramp-Fasciculation Syndrome
(DERMAN MEDICAL PUBL, 2016-01-01) Dikmen, Pinar Yalinay; Aysevener, Elif Onur
Cramp-fasciculation syndrome is one of the peripheral nerve hyperexcitability disorders and presents muscle aching, cramps, stiffness and exercise intolerance. Fasciculation and cramps can be seen both in healthy individuals and in those with fatal diseases, such as Amyotrophic Lateral Sclerosis. We present a 27-year-old male patient, professional soccer player with fasciculations and cramps in bilateral gastrocnemius-soleus complex. The patient complained about having to stop playing soccer because of muscle cramps and twitches in both calves, which had started 3 years earlier. After completing all laboratory and electrophysiological examinations, the patient was diagnosed as cramp-fasciculation syndrome. The aim of this paper was to present a rare case of cramp-fasiculation syndrome and discuss if the syndrome is benign or pioneer of a severe pathological process.
A Case With New-Onset Neuromyelitis Optica Spectrum Disorder Following COVID-19 mRNA BNT162b2 Vaccination
(LIPPINCOTT WILLIAMS \& WILKINS, 2022-01-01) Caliskan, Ilay; Bulus, Eser; Afsar, Nazire; Altintas, Ayse
Introduction: In the midst of the coronavirus disease of 2019 pandemic, active immunization by effective vaccination gained utmost importance in terms of global health. The messenger RNA (mRNA) vaccines are novel strategies requiring clinical surveillance for adverse events. Case Report: We report a 43-year-old previously healthy female with an optic neuritis attack 24 hours following immunization with the second dose of coronavirus disease of 2019 mRNA BNT162b2 vaccine. A second transverse myelitis attack together with an elevated anti-AQP-4 antibody titer confirmed the diagnosis of neuromyelitis optica spectrum disorder. Conclusion: Our case identifies the BNT162b2 vaccine as a possible trigger for neuromyelitis optica spectrum disorder. This rare and potentially coincidental event has no implications for vaccine administration practices. However, further research is needed to elucidate the effects of mRNA vaccines on humoral and cell-mediated immunity.
A Cell Culture Chip with Transparent, Micropillar-Decorated Bottom for Live Cell Imaging and Screening of Breast Cancer Cells
(MDPI, 2022-01-01) Ermis, Menekse; Antmen, Ezgi; Kuren, Ozgur; Demirci, Utkan; Hasirci, Vasif
In the recent years, microfabrication technologies have been widely used in cell biology, tissue engineering, and regenerative medicine studies. Today, the implementation of microfabricated devices in cancer research is frequent and advantageous because it enables the study of cancer cells in controlled microenvironments provided by the microchips. Breast cancer is one of the most common cancers in women, and the way breast cancer cells interact with their physical microenvironment is still under investigation. In this study, we developed a transparent cell culture chip (Ch-Pattern) with a micropillar-decorated bottom that makes live imaging and monitoring of the metabolic, proliferative, apoptotic, and morphological behavior of breast cancer cells possible. The reason for the use of micropatterned surfaces is because cancer cells deform and lose their shape and acto-myosin integrity on micropatterned substrates, and this allows the quantification of the changes in morphology and through that identification of the cancerous cells. In the last decade, cancer cells were studied on micropatterned substrates of varying sizes and with a variety of biomaterials. These studies were conducted using conventional cell culture plates carrying patterned films. In the present study, cell culture protocols were conducted in the clear-bottom micropatterned chip. This approach adds significantly to the current knowledge and applications by enabling low-volume and high-throughput processing of the cell behavior, especially the cell-micropattern interactions. In this study, two different breast cancer cell lines, MDA-MB-231 and MCF-7, were used. MDA-MB-231 cells are invasive and metastatic, while MCF-7 cells are not metastatic. The nuclei of these two cell types deformed to distinctly different levels on the micropatterns, had different metabolic and proliferation rates, and their cell cycles were affected. The Ch-Pattern chips developed in this study proved to have significant advantages when used in the biological analysis of live cells and highly beneficial in the study of screening breast cancer cell-substrate interactions in vitro.