Araştırma Çıktıları

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Author: search.filters.author.Acikel Elmas, MerveHas files: Yes

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    p-Coumaric acid has an ameliorative effect on peptic ulcer: a macroscopic, microscopic and biochemical analysis
    (MARMARA UNIV, FAC MEDICINE, 2021-01-01) Kolgazi, Meltem; Oztosun, Gulsen; Yalcin, Muge; Unan, Zehra Neslisah; Arsoy, Edanur; Oral, Simge; Cilingir, Sumeyye; Acikel Elmas, Merve; Arbak, Serap
    Objective: p-Coumaric acid is commonly found in edible plants in nature and is known to be an effective antioxidant. This study aimed to investigate the therapeutic effects of p-coumaric acid on ethanol-induced gastric ulcer model Materials and Methods: After an 18-hour starvation period, the ulcer was induced in male Sprague-Dawley (250-300) rats by intragastric administration of 75\% ethanol. An hour after ulcer induction, p-coumaric acid (250 mg/kg) suspended in 1 ml tween-80 was administered intragastrically. The control and ulcer groups received 1 ml tween-80, One hour later, all rats were euthanized and stomach samples were collected for macroscopic examination, histological evaluation, and measurement of myeloperoxidase (MPO) activity, malondialdehyde (MDA), and glutathione (GSH) levels. Results: Ethanol induction resulted in gastric epithelial and mucosa' injury, increased MPO activity and MDA levels
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    The alterations of blood-testis barrier in experimental testicular injury models
    (MARMARA UNIV, FAC MEDICINE, 2022-01-01) Ercan, Feriha; Acikel Elmas, Merve
    The blood-testis barrier is found between the Sertoli cells and divides the seminiferous tubule epithelium into basal and adluminal compartments. The germinal cell renewal, differentiation and cell cycle progression up to the preleptotene spermotocytes stage take place in the basal compartment, however, meiosis, spermiogenesis and spermiation take place in the adluminal compertment. The blood-testis barrier consists of tight junctions as well as ectoplasmic specialisations, desmosomes and gap junctions to create specific microenvironment for the completion of spermatogenesis to form spermatozoa. The blood-testis barrier is not a static ultrastructure, it undergoes extensive restructuring during the seminiferous tubule epithelial cycle of spermatogenesis to allow the transit of preleptotene spermotocytes at the blood-testis barrier from basal compartment towards the adluminal compartment. The functions of the blood-testis barrier include preventing the transport of biomolecules into the paracellular space, forming an immunological barrier, separating cellular processes during the spermatogenic epithelial cycle, and establishing the cellular polarity of the seminiferous tubule. However, various environmental conditions, chemotherapeutic agents, toxic substances and lifestyle have degenerative effects on blood-testis barrier, resulting in testicular damage, altered sperm parameters and ultimately male infertility. The alterations in morphological and molecular organization of blood-testis barrier in different experimentally induced testis injury models arc reviewed in this article.
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    Ameliorating effects of exercise on disrupted epididymal sperm parameters in high fat diet-induced obese rats
    (MARMARA UNIV, FAC MEDICINE, 2019-01-01) Acikel Elmas, Merve; Arbak, Serap; Ercan, Feriha
    Objective: Obesity causes male infertility problems and affects the sperm quality. Recent studies have shown that exercise has positive effects on male fertility. The present study aimed to show the effects of swimming exercise on the epididymal sperm number, motility and morphology in hight fat diet (HFD)-induced obese rats. Materials and Methods: Four experimental groups (n=8 in each group) were formed. Standard (STD) and STD+Exercise (STD+EXC) groups were fed with standard rat diet (6\% of calories as fat)