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Author: search.filters.author.Demirci, Gulsen TukenmezSubject: search.filters.subject.Pemphigus

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    Hepatitis C and hepatitis B virus infections in the etiopathogenesis of pemphigus
    (SOC BRASILEIRA DERMATOLOGIA, 2014-01-01) Demirci, Gulsen Tukenmez; Aydingoz, Ikbal Esen; Mansur, Ayse Tulin; Atis, Guldehan; Altunay, Ilknur Kivanc
    BACKGROUND: Previous studies have shown that some viral infections may be triggers for autoimmune diseases. The role of viral infections in the etiopathogenesis of pemphigus has also been investigated. OBJECTIVES: To investigate the relationship between pemphigus and the hepatitis B and C virus infections. METHODS: This retrospective study included 62 patients with pemphigus and 50 healthy controls of matching ages and genders. The control group included relatives who accompanied the orthopedic patients to the hospital but had no history of systemic and/or autoimmune diseases. RESULTS: The group of patients with pemphigus was composed of 43 (69.3\%) females and 19 (29.7\%) males, and the mean age was 48.08 +/- 15.38. The hepatitis C virus antibody was negative in all of the patients. Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb), or both, were studied in 44 of the 62 patients. Two (4.3\%) of these patients were positive for HBsAg and found to have HBV infection. Fourteen of them were HBsAb positive. Two (4\%) of the 50 control subjects showed hepatitis C virus antibody positivity, while only 1 (2\%) patient with pemphigus displayed HBsAg positivity. There was no statistically significant difference between the two groups for hepatitis B and C virus infections. CONCLUSIONS: This study does not support an association between pemphigus and hepatitis B and/or C virus infections.
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    Risk Factors in Pemphigus
    (DERI ZUHREVI HASTALIKLAR DERNEGI, 2011-01-01) Demirci, Gulsen Tukenmez; Mansur, Ayse Tulin; Aydingoz, Ikbal Esen
    Background and Design: There have been reports suggesting the involvement of environmental factors in the disease process of pemphigus. In this study, we aimed to find out the risk factors which could play role in the etiopathogenesis in our pemphigus patients. Material and method: A total of 42 patients (15 male and 27 female) who were diagnosed as pemphigus with histopathological and direct immunoflurosence examinations in our clinic between the years 1998-2004, were interviewed for assessment of regarding with the subjects of the demographic properties, occupational groups, educational level, the number of pregnancies, stressfull life events, diet habits, smoking and alcohol consumption before the onset of the disease and the results were compared to 42 age and gender-matched controls with similar socioeconomic circumstances. Results: Working in agriculture and livestock, multi-parity, absence of smoking and stressfull life events were found to be statistically significant in pemphigus patients than in controls. Conclusion: Working in agriculture and livestock, multi-parity, absence of smoking and stressfull life events were assumed to play role in the etiopathogenesis and course of pemphigus. (Turkderm 2011