Araştırma Çıktıları

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Author: search.filters.author.Ercan, MujganSubject: search.filters.subject.biological variation

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    Determining biological variation of serum parathyroid hormone in healthy adults
    (CROATIAN SOC MEDICAL BIOCHEMISTRY \& LABORATORY MEDICINE, 2019-01-01) Ercan, Mujgan; Akbulut, Emis Deniz; Avci, Esin; Yucel, Cigdem; Oguz, Esra Firat; Turhan, Turan; Serdar, Muhittin
    Introduction: Measurement of parathyroid hormone (PTH) is essential in the investigation and management of calcium metabolism disorders. To assess the significance of any assay result when clinical decision making biological variation (BV) of the measurand must be taken into consideration. The aim of the present study is determining the BV parameters for serum PTH. Materials and methods: Blood samples were taken at weekly intervals from 20 healthy subjects for ten weeks in this prospective BV study. Serum ``intact PTH{''} concentrations were measured with electrochemiluminescence method. Biological variation parameters were estimated using the approach proposed by Fraser. Results: The values of within-subject biological variation (CVI), between-subject biological variation (CVG), analytical variation (CVA), reference change value (RCV) and individuality index (II) for serum PTH were 21.1\%, 24.9\%, 3.8\%, 59.4\% and 0.8\%, respectively. Within-subject biological variation and CVG were also determined according to gender separately
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    Biological variation and reference change value data for serum copper, zinc and selenium in Turkish adult population
    (WALTER DE GRUYTER GMBH, 2021-01-01) Bal, Ceylan; Erdogan, Serpil; Gok, Gamze; Nural, Cemil; Ozbek, Betul; Ercan, Mujgan; Serdar, Muhittin; Erel, Ozcan
    Objectives: Calculation of biological variation (BV) components is very important in evaluating whether a test result is clinically significant. The aim of this study is to analyze BV components for copper, zinc and selenium in a cohort of healthy Turkish participants. Methods: A total of 10 serum samples were collected from each of the 15 healthy individuals (nine female, six male), once a week, during 10 weeks. Copper, zinc and selenium levels were analyzed by atomic absorption spectrometer. BV parameters were calculated with the approach suggested by Fraser. Results: Analytical variation (CVA), within-subject BV (CVI), between-subject BV (CVG) values were 8.4, 7.1 and 4.3 for copper