Araştırma Çıktıları

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Author: search.filters.author.Kolgazi, Meltem

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    Morphological evaluation of the effects of exercise on high-fat-diet-induced liver damage in rats
    (AVES, 2020-01-01) Elmas, Merve Acikel; Atay, Nilsu; Ozakpinar, Ozlem Bingol; Arbak, Serap; Kolgazi, Meltem; Sener, Goksel; Ercan, Feriha
    Background/Aims: This study was aimed to investigate the protective effects of swimming on nonalcoholic fatty liver disease associated with high-fat-diet-induced obesity using microscopic and biochemical parameters. Materials and Methods: Sprague-Dawley male rats were fed either standard chow (STD group
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    p-Coumaric acid has an ameliorative effect on peptic ulcer: a macroscopic, microscopic and biochemical analysis
    (MARMARA UNIV, FAC MEDICINE, 2021-01-01) Kolgazi, Meltem; Oztosun, Gulsen; Yalcin, Muge; Unan, Zehra Neslisah; Arsoy, Edanur; Oral, Simge; Cilingir, Sumeyye; Acikel Elmas, Merve; Arbak, Serap
    Objective: p-Coumaric acid is commonly found in edible plants in nature and is known to be an effective antioxidant. This study aimed to investigate the therapeutic effects of p-coumaric acid on ethanol-induced gastric ulcer model Materials and Methods: After an 18-hour starvation period, the ulcer was induced in male Sprague-Dawley (250-300) rats by intragastric administration of 75\% ethanol. An hour after ulcer induction, p-coumaric acid (250 mg/kg) suspended in 1 ml tween-80 was administered intragastrically. The control and ulcer groups received 1 ml tween-80, One hour later, all rats were euthanized and stomach samples were collected for macroscopic examination, histological evaluation, and measurement of myeloperoxidase (MPO) activity, malondialdehyde (MDA), and glutathione (GSH) levels. Results: Ethanol induction resulted in gastric epithelial and mucosa' injury, increased MPO activity and MDA levels