Araştırma Çıktıları
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Item What does the Data of 354,725 Patients from Turkey Tell Us About Cervical Smear Epithelial Cell Abnormalities? - The Epithelial Cell Abnormality Rate is Increasing - Quality Control Studies and Corrective Activity are Musts(DE GRUYTER OPEN LTD, 2017-01-01) Turkmen, Ilknur Cetinaslan; Usubutun, Alp; Cakir, Asli; Aydin, Ozlem; Bolat, Filiz Aka; Akbulut, Metin; Altinay, Serdar; Arici, Sema; Aslan, Figen; Astarci, Muzeyyen; Bagir, Emine Kilic; Bas, Yilmaz; Bassullu, Nuray; Celik, Betul; Cetiner, Handan; Cobanoglu, Bengu; Aydin, Abdullah; Demir, Hale; Dogan, Hayriye Tatli; Eken, Kamile Gulcin; Erhan, Selma Sengiz; Erdogan, Gulgun; Erdogan, Kivilcim Eren; Eren, Funda; Ersoz, Safak; Firat, Pinar; Gurses, Iclal; Haberal, Nihan; Kahraman, Dudu Solakoglu; Kamali, Gulcin Harman; Karabulut, Yasemin Yuyucu; Kefeli, Mehmet; Koyuncuoglu, Meral; Koseoglu, R. Dogan; Muezzinoglu, Bahar; Onal, Binnur; Onder, Sevgen; Ozcan, Zuhal; Kimiloglu, Elife; Ozer, Hatice; Sonmez, F. Cavide; Sahin, Sevinc; Sahin, Nurhan; Yalta, TulinObjective: There is no other screening program close to the success rate of PAP test. Cervical cytology constitutes a large workload so that quality control in cervical cytology is important for the quality assurance of pathology laboratories. Material and Method: In this study, we collected the cervical cytology results from all over Turkey and discussed the parameters influencing the quality of the PAP test. The study was conducted with Turkish gynaecopathology working group and 38 centers (totally 45 hospitals) agreed to contribute from 24 different cities. The study was designed to cover the cervical cytology results during 2013. The results were evaluated from the data based on an online questionnaire. Results: The total number of Epithelial Cell Abnormality was 18,020 and the global Epithelial Cell Abnormality rate was 5.08\% in the total 354,725 smears and ranging between 0.3\% to 16.64\% among centers. The Atypical squamous cells/Squamous intraepithelial lesion ratios changed within the range of 0.21-13.94 with an average of 2.61. When the centers were asked whether they performed quality assurance studies, only 14 out of 28 centers, which shared the information, had such a control study and some quality parameters were better in these centers. Conclusion: There is an increase in the global Epithelial Cell Abnormality rate and there are great differences among centers. Quality control studies including the Atypical squamous cells/Squamous intraepithelial lesion ratio are important. Corrective and preventive action according to quality control parameters is a must. A cervical cytology subspecialist in every center can be utopic but a dedicated pathologist in the center is certainly needed.Item Six-year distribution pattern of hepatitis C virus in Turkey: a multicentre study(TAYLOR \& FRANCIS LTD, 2016-01-01) Altindis, Mustafa; Dal, Tuba; Akyar, Isin; Karatuna, Onur; Gokahmetoglu, Selma; Ulger, Seda Tezcan; Kulah, Canan; Uzun, Berrin; Sener, Asli Gamze; Ozdemir, Mehmet; Aydogan, Sibel; Kuskucu, Mert Ahmet; Midilli, Kenan; Otlu, Baris; Celen, Mustafa Kemal; Buruk, Kurtulus; Guducuoglu, HuseyinHepatitis C infection is a public health problem. The aim of this retrospective study was to determine the distribution of hepatitis C virus (HCV) genotypes in seven regions of Turkey, by evaluating 7002 patients with chronic HCV in a six-year period. During the 2009-2014 period, serum/plasma samples from 7002 new consecutive HCV RNA positive patients were collected. The female patients were 3867 (55.2\%). The genotype distribution of HCV patiens was evaluated by ages and years. Statistical analysis was performed by using the Mann-Whitney test and the chi(2) analysis. During the six-year period, genotype 1b was the most common genotype (67.7\%) followed by untypeable genotype 1 (7.7\%), genotype 4 (7.3\%) and genotype 3 (6.7\%). In 2014, genotype 3 was the second most common one (11.3\%) and genotype 4 was the third most common one (9.8\%). In the group with <25 years old patients, genotype 1b was most common (78.48\%, 62/79) between the years of 2009 and 2011, whereas genotype 3 (34.8\%, 86/247), between the years of 2012 and 2014. Genotype 1b was the most common in the groups between 26 and 35 years, 36 and 45 years, 46 and 55 years, 56 and 65 years. The rate of genotype 3 was increased from 4.78\% to 10.06\% and the rate of genotype 4 was increased from 1.3\% to 3.84\%, from 2009-2011 to 2012-2014. In recent years, genotypes 3 and 4 have gained importance. New therapeutic strategies and survey studies may be required for the modified HCV genotype pattern.Item Recommendations for the selection of techniques and components used in congenital heart surgery in Turkey(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2012-01-01) Undar, Akif; Haydin, Sertac; Erek, Ersin; Yivli, Perihan; Odemis, Ender; Agirbasli, Mehmet; Alkan-Bozkaya, Tijen; Turkoz, Ayda; Turkoz, Riza; Sasmazel, Ahmet; Karaci, Ali Riza; Cicek, Ali Ekber; Yalcinbas, Yusuf; Akcevin, Atif; Sarioglu, Tayyar; Bakir, IhsanThere is no standard for the selection of technical and mechanical components (heart-lung machine system, oxygenator, arterial and venous cannulae, arterial filter and other specifically-designed components and devices) used in cardiopulmonary bypass in Turkey. The cost of the component plays a significant role in the selection, as well as the preference of the facility. Only a limited number of hospitals decide which components to be used based on scientific data. Studies have confirmed that selected novel techniques and components having no basis of scientific justification may pose risk for the life of the patient in the short- and long-term. The objectives of this study are to show how to use quality-control procedures and scientific data for the selection of novel techniques and components and to share, also, recent techniques experienced to minimize the complication risk after surgery.Item Seroprevalence of hepatitis B and C virus infections and risk factors in Turkey: a fieldwork TURHEP study(ELSEVIER SCI LTD, 2015-01-01) Tozun, N.; Ozdogan, O.; Cakaloglu, Y.; Idilman, R.; Karasu, Z.; Akarca, U.; Kaymakoglu, S.; Ergonul, O.The present study was designed to determine the seroprevalence of hepatitis B and C virus (HBV, HCV) infections and risk factors in the Turkish general population. Participants were enrolled from urban and rural areas of the predetermined 23 EUROSTAT NUTS 2 region. A two-stage stratified sampling method was used to select participants from these regions (n = 5460Item History of Lung Transplantation(BILIMSEL TIP PUBLISHING HOUSE, 2016-01-01) Dabak, Gul; Senbaklavaci, OmerHistory of lung transplantation in the world can be traced back to the early years of the 20th century when experimental vascular anastomotic techniques were developed by Carrel and Guthrie, followed by transplantation of thoracic organs on animal models by Demikhov and finally it was James Hardy who did the first lung transplantation attempt on human. But it was not until the discovery of cyclosporine and development of better surgical techniques that success could be achieved in that field by the Toronto Lung Transplant Group led by Joel Cooper. Up to the present day, over 51.000 lung transplants were performed in the world at different centers. The start of lung transplantation in Turkey has been delayed for various reasons. From 1998 on, there were several attempts but the first successful lung transplant was performed at Sureyyapasa Hospital in 2009. Today there are four lung transplant centers in TurkeyItem ASSESSMENT OF THE TURKEY'S ELECTRIC POWER POLICIES IN TERMS OF SUSTAINABILITY(VINCA INST NUCLEAR SCI, 2014-01-01) Atis, Selcuk; Onat, Nevzat; Guney, K. R. IrfanThis study, using statistical data published by the Turkish Electricity Transmission Company, analyzes key parameters such as installed capacity and energy demand growth rates, investment plans and emission rates, taking into consideration the expected increase in use through the year 2023. The results of the analyses were compared to relevant data from around the world. The weight of domestic and especially renewable resources in investment plans for the next 10 years was discussed. Recommendations for an investment plan to support sustainable development in Turkey are listed. Consequently, the lack of investment in domestic and renewable energy projects decreases the competitive power of Turkey vis-a-vis Organisation for Economic Co-Operation and Development countries in terms of many parameters. For a sustainable development, the country must make significant changes in its foreign-dependent energy production policies. Any future policies must encourage supplying local resources to meet the continuously increasing demand. Qualifications for incentive mechanisms applied to investments in renewable energy should be developed. The impact of the private sector on the installation of new plants must also be increased by quickly completing the privatization processItem A possible founder mutation in FZD6 gene in a Turkish family with autosomal recessive nail dysplasia(BMC, 2019-01-01) Saygi, Ceren; Alanay, Yasemin; Sezerman, Ugur; Yenenler, Asli; Ozoren, NesrinBackgroundAutosomal recessive nail dysplasia is characterized by thick and hard nails with a very slow growth on the hands and feet. Mutations in FZD6 gene were found to be associated with autosomal recessive nail dysplasia in 2011. Presently, only seven mutations have been reported in FZD6 geneItem IODINE DEFICIENCY IN PREGNANT WOMEN LIVING IN WESTERN TURKEY (EDIRNE)(EDITURA ACAD ROMANE, 2016-01-01) Celik, H.; Guldiken, S.; Celik, O.; Taymez, F.; Dagdeviren, N.; Tugrul, A.Objective. Data about iodine status in pregnant women in Turkey is not sufficient. We aimed to determine the iodine status, goiter prevalence, iodized salt consumption among first trimester pregnant women living in Edirne. Design and Setting. Cross-sectional study was performed on pregnant women living in Edirne. Subjects and Methods. A total of 275 pregnant women in their first trimester were examined regarding iodized salt use, median urinary iodine concentration (UIC), presence or absence of goitre and thyroid function. Goitre status was determined by palpation. Participants filled out a questionnaire, which included questions regarding sociodemographic features, iodized salt consumption, knowledge, and behavior regarding iodine deficiency. UIC was measured using colorimetric method based on Sandell-Kolthoff reaction. Thyroid hormones and TSH were measured by chemiluminescence immunoassays. Results. While the proportion of iodized salt use was 96.6\%, UIC was below 150 mu g/L in 88.4 \% of the women. The median UIC was 77 mu g/L, indicating insufficient iodine intake. Total goitre rate was 19.3\%. Conclusions. Our study shows that iodine deficiency is a serious problem among pregnant women in Edirne. We suggest that pregnant women living in Edirne should be supplemented by iodine-containing preparations in addition to iodized salt.Item Biomass smoke exposure as a serious health hazard for women(TURKISH ASSOC TUBERCULOSIS \& THORAX, 2013-01-01) Babalik, Aylin; Bakirci, Nadi; Taylan, Mahsuk; Bostan, Leyla; Kiziltas, Sule; Basbug, Yelda; Calisir, Haluk C.Introduction: Lung diseases caused by biomass exposure cause a significant health hazard particularly amongst women. The present study was designed to investigate biomass exposure in women suffering from lung disease. Materials and Methods: A total of 100 women {[} mean (SD) age: 55.13 (17.65) years] hospitalized for chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, tuberculosis or interstitial lung disease were included in this study conducted between September 2008-March 2009 in three chest disease clinics at Sureyyapasa Chest Diseases and Chest Surgery Training and Research Hospital. Data collection on biomass exposure was based on application of hospital-based survey questionnaire including items on occupation, level of education, place of birth (location, region), exposure to biomass fuel fumes for heating and cooking purposes (animal dung, wood, charcoal, dried plant) and years of exposure with animal dung, wood, charcoal, dried plant. Results: COPD in 22\% patients, lung carcinoma in 12\%, bronchitis in 8\%, tuberculosis in 26\%, and interstitial lung disease in 17\% were the diagnosis for hospitalization. The most identified occupation was housewifery 86\%. Active, former and nonsmokers composed 6\%, 22\% and 72\% of the population. Birth place was village in 67\% patients while districts in 9\%. According to regional distribution, the most common place of birth was Central Anatolia region in (29\%). Exposure to biomass fuels was identified in all of patients including wood (92\%), animal dung (30\%), charcoal (23\%), and dry plant (23\%). Mean (SD) years of exposure was identified to be 52.6 (17.9) years for wood, 40.8 (17.9) years for animal dung, 48.1 (20.8) years for dry plant and 38.5 (21.4) years for charcoal. The most common type of biomass exposure was wood in village (97\%), city (79\%) and county (89\%). Conclusion: Findings indicating impact of biomass exposure in women seem to emphasize the need for analytic epidemiologic studies assessment measuring biomass exposure levels-particularly for women and young children.Item Insanity, belonging and citizenship: mentally ill people who went to and/or returned from Europe in the Late Ottoman Era(SAGE PUBLICATIONS LTD, 2016-01-01) Artvinli, FatihThe Ottoman Empire, which encompassed a vast territory, had several facilities for the protection and treatment of the mentally ill. By the late nineteenth century, some wealthy families had begun to send their patients to mental hospitals in Europe for better treatment. During the same period, the process of repatriation of mental patients who were Ottoman subjects also began. These processes, which resulted in complex bureaucratic measures, later found a place in regulations and laws. The Ottoman Empire had an additional incentive to protect mentally-ill patients during the Second Constitutional Era, when discussions about citizenship' reappeared. This article examines the practices of sending mentally-ill people to Europe and the repatriation of mentally-ill Ottoman subjects from European countries.