Araştırma Çıktıları

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    Effects of Irisin Compared with Exercise on Specific Metabolic and Obesity Parameters in Female Mice with Obesity
    (MARY ANN LIEBERT, INC, 2020-01-01) Ozgor, Bahar Yuksel; Demiral, Irem; Zeybek, Umit; Celik, Faruk; Buyru, Faruk; Yeh, John; Bastu, Ercan
    Objective: We aimed to analyze the changes in metabolic parameters after administration of irisin to obese female mice. Materials and Methods: Sixty mice aged 5-6 weeks were randomized into three groups as irisin, exercise, and control. The control and irisin group remained sedentary, whereas the exercise group started free wheel exercising 6 weeks after the start of the study. The irisin group received irisin after 20 weeks. All mice were sacrificed at the 22nd week of the study, and obesity-related metabolic parameters were analyzed. Results: There was no significant difference between the irisin and exercise groups in weight gain (P > 0.05). By contrast, weight gain in the control group was significantly higher compared with the irisin and exercise groups (P < 0.05). Serum bone morphogenetic protein (BMP), ghrelin, insulin, kisspeptin, leptin, and visfatin levels were statistically lower in the irisin and exercise groups compared with the control group, but no significance was detected between the irisin and exercise groups (P < 0.05 for all parameters). Conclusion: Similar to the effect of exercise, irisin injections resulted in the amelioration of certain obesity-related parameters such as the concentration of adipokines, BMP4, insulin, and ghrelin. Its role as a potential alternative to exercise needs to be further studied.
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    Morphological evaluation of the effects of exercise on high-fat-diet-induced liver damage in rats
    (AVES, 2020-01-01) Elmas, Merve Acikel; Atay, Nilsu; Ozakpinar, Ozlem Bingol; Arbak, Serap; Kolgazi, Meltem; Sener, Goksel; Ercan, Feriha
    Background/Aims: This study was aimed to investigate the protective effects of swimming on nonalcoholic fatty liver disease associated with high-fat-diet-induced obesity using microscopic and biochemical parameters. Materials and Methods: Sprague-Dawley male rats were fed either standard chow (STD group
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    Gut Microbiota and Oral Contraceptive Use in Overweight and Obese Patients with Polycystic Ovary Syndrome
    (ENDOCRINE SOC, 2020-01-01) Eyupoglu, Nesrin Damla; Ergunay, Koray; Acikgoz, Aylin; Akyon, Yakut; Yilmaz, Engin; Yildiz, Bulent Okan
    Context: Polycystic ovary syndrome (PCOS) is a common and complex endocrine disorder. Emerging animal and human data point to various changes in microbiota that could be linked with the syndrome. However, the effects of therapeutic approaches on gut microbial composition in women with PCOS remain unknown. Objective: We aimed to assess whether gut microbial composition is altered in PCOS and to determine the potential impact of oral contraceptive (OC) use on gut microbiota. Design: Prospective observational study. Setting: Tertiary referral hospital. Patients and Other Participants: The study included 17 overweight/obese patients with PCOS and 15 age- and body mass index-matched healthy control women. Main Outcome Measures: At baseline, clinical, hormonal, and metabolic evaluations and gut microbial composition assessment by 16S rRNA gene amplicon sequencing were performed for both groups. All measurements were repeated in patients after receiving an OC along with general lifestyle advice for 3 months. Results: Alpha and beta diversity did not show a difference between patients with PCOS and healthy controls at baseline and remained unaltered after 3 months of OC use in the PCOS group. Relative abundance of Ruminococcaceae was higher in PCOS (P= 0.006) and did not show a significant change after treatment. Conclusion: Women with PCOS have an increased abundance of Ruminococcaceae, whereas short-term OC use does not alter compositional features of gut microbiota in the syndrome.
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    The Association Between Obesity, Being Overweight and Socio-economic Status Among School-Age Children Living in Big Cities
    (BURSA ULUDAG UNIV, 2021-01-01) Aka, Sibel; Arapoglu, Mujde
    Introduction: Obesity has become a serious health concern worldwide. Risk factors of obesity are different in urban and rural areas. The aim of this study was to determine the risk factors related to obesity and being overweight among children in low and high socio-economic groups in a big metropolitan city, Istanbul. Materials and Methods: A cross-sectional study was carried out on 490 school-age children between 5 and 15 years. Low and high socio-economic groups were determined according to socio-economic status (SES). Socio-demographic characteristics of children were collected from the parents. Results: The effect of having frequent snacks rich in carbonhydrates (p=0,001) and sedentary lifestyles (p=0,001) on BMI was significant in both SES groups. In high SES group, BMI of the <10 years boys was significantly higher than that of the <10 years girls