Araştırma Çıktıları

Permanent URI for this communityhttps://hdl.handle.net/11443/931

Browse

Subject: search.filters.subject.Cerebral vasospasm

Search Results

Now showing 1 - 3 of 3
  • Thumbnail Image
    Item
    Effects of Arginine Vasopressin and V1 Receptor Antagonist on Cerebral Vasospasm Secondary to Subarachnoid Hemorrhage: An Experimental Study
    (TURKISH NEUROSURGICAL SOC, 2018-01-01) Yilmaz, Dervis Mansuri; Haciyakupoglu, Ersin; Diril, Serkan; Sencar, Leman; Akgul, Erol; Polat, Sait; Haciyakupoglu, Sebahattin; Nazlican, Ersin
    AIM: To examine morphological, radiological and biochemical effects of arginine vasopressin ( AV) and V1 receptor antagonist on cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) in rabbits. MATERIAL and METHODS: Forty male New Zealand white rabbits were randomly divided into four groups comprising 10 rabbits each. The groups were
  • Thumbnail Image
    Item
    The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery
    (TURKISH NEUROSURGICAL SOC, 2016-01-01) Orakdogen, Metin; Uslu, Serap; Emon, Selin Tural; Somay, Hakan; Meric, Zeynep Cingu; Hakan, Tayfun
    AIM: Oxidation products following subarachnoid hemorrhage (SAH) are among the causative substances of cerebral vasospasm and poor outcome. Ozone (O-3) is a gas that contains three atoms of oxygen with a cyclic structure. It has been suggested that application of low-dose ozone has an antioxidant effect and provides resistance to oxidative stress. We investigated the effect of oxygen-ozone therapy on rat femoral artery vasospasm. MATERIAL and METHODS: Twenty-four male Sprague-Dawley rats were randomly separated into vasospasm, vasospasm + ozone and control groups. The femoral artery vasospasm model was used. Rats in the vasospasm + ozone group were given 4 mL of ozone (20 mu/mL) daily for 7 days. Femoral arteries were examined by light microscopy for histological changes and morphometric analysis. Kruskal Wallis test and Mann Whitney U tests were used for the statistical analysis. The values of p<0.01 and p<0.05 were recognized as statistically significant. RESULTS: Ozone treatment reduced the morphometric changes as irregularity of the elastic lamina, disruption of the endothelial cells, vacuolization and hemorrhages that caused by vasospasm. The measurements of the wall thickness (p=0.003
  • Thumbnail Image
    Item
    Haemodynamic Augmentation in the Treatment of Vasospasm in Aneurysmal Subarachnoid Hemorrhage
    (TURKISH NEUROSURGICAL SOC, 2012-01-01) Gura, Melek; Elmaci, Ilhan; Cerci, Ajlan; Sagiroglu, Esra; Coskun, K. Kenan
    AIM: Hypertension, hypervolemia and hemodilution therapy is a common approach to cerebral vasospasm after subarachnoid haemorrhage. This study is designed to see the difference of moderate or aggressive hypervolemia supported with induced hypertension in symptomatic vasospasm detected with transcranial Doppler ultrasonography (TCD) measurements. MATERIAL and METHODS: Fifty eight patients who had aneurysm clipping and were admitted to the neurointensive care unit were treated with normovolemia and induced hypertension (n=35) or hypervolemia supported with induced hypertension (n=23) targeting a mean arterial pressure of 110-130 mm Hg and central venous pressure of 8-12 mm Hg. Daily TCD, fluid intake, fluid balance and haemodynamic values were recorded for 14 days. RESULTS: There were no differences detected in mean arterial pressure, central venous pressure, hematocrit values, fluid balance and middle cerebral artery flow velocities between the two groups through 14 days (p > 0.05). Hyponatremia, pulmonary edema and cerebral ischemia were observed as complications. CONCLUSION: Hypervolemia adds no benefit compared to normovolemia in the treatment of vasospasm occurred as a result of subarachnoid hemorrhage. Induced hypertension establishes the haemodynamic augmentation to prevent and treat vasospasm.