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Subject: search.filters.subject.hemorrhagic shock

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    Comparison of warm fluid and cold fluid resuscitation during uncontrolled hemorrhagic shock model in rats
    (TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2017-01-01) Dilmen, Serkan; Eryilmaz, Mehmet; Balkan, Salih Mujdat; Serdar, Muhittin; Durusu, Murat; Yildirim, Ali Osman; Dilmen, Sanem Aslihan
    BACKGROUND: This study was designed to compare the effects of resuscitation with cold and warm fluid on survival time, rate and volume of hemorrhage, hemodynamics, hypothermia, coagulopathy, acid-base balance, hematocrit, lactate, and base deficit during uncontrolled hemorrhagic shock (HS) model in rats. METHODS: HS model was created with splenic vascular and parenchymal injury in 29 rats under ketamine and xylazine anesthesia. Thirty minutes after the hemorrhage, the rats were randomized to receive 14.5 mL/kg 0.9\% sodium chloride solution at either 24 degrees C (Group I
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    Ischemia-modified albumin and the IMA/albumin ratio in the dignosis and staging of hemorrhagic shock: A randomized controlled experimental study
    (TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2020-01-01) Turedi, Suleyman; Sahin, Aynur; Akca, Metehan; Demir, Selim; Kose, Gokcen Derya Reis; Cekic, Arif Burak; Yildirim, Mehmet; Yulug, Ersin; Mentese, Ahmet; Turkmen, Suha; Acar, Sami
    BACKGROUND: To determine the value of ischemia-modified albumin (IMA) and IMA/albumin ratio (IMAR) in the diagnosis and staging of hemorrhagic shock (HS). METHODS: A pressure-targeted HS model was established in this study. The control and shock groups were monitored for 30 min and 60 min to simulate varying durations of exposure to HS. All subjects underwent invasive arterial monitoring during the experiment and were further divided into mild and severe shock groups based on decreases in mean arterial pressure (MAP). Biochemical and histologic comparisons were performed between the groups. RESULTS: Our results revealed higher IMA, IMAR, lactate, total oxidant status (TOS) and oxidative stress index (OSI) levels in both the 30- and 60-min shock groups compared to the control group. Concerning MAP-based shock staging, IMA, IMAR, lactate, TOS and OSI levels in the 30-min and 60-min mild and severe shock groups were higher than those of the controls. However, there was no significant difference between the mild and severe shock groups. A significant correlation was determined between all the biomarkers evaluated and HS-induced damage in various organs. This correlation was highest in lactate and IMAR levels. CONCLUSION: IMA and IMAR levels may be used in the early diagnosis of HS and also have the potential for use in determining the severity of HS. IMA and IMAR measurement may also be considered as an alternative or in addition to lactate measurement in the diagnosis of HS.