Kiral, EylemKirel, BirgulHavan, MerveKeskin, MehmetKaraoglan, MuratYildirim, AhmetKangin, MuratTalay, Mehmet NurUrun, TubaAltug, UmitKesici, SelmanTufan, ErennurKacmaz, EbruBozan, GurkanAzapagasi, EbruUysal Yazici, MutluOzturk, ZeynelabidinYesilbas, OsmanKaraguzel, GulayKaya, GulayBarlas, UlkemDuyu, MuhteremBoyraz, MerveSevketoglu, EsraAkcay, NihalHancili, SunaGuven, AylaDursun, OguzTekerek, Nazan UlgenOzcifci, GokcenYazici, PinarTuranli, EdaKendirli, TanilKahveci, FevziYetimakman, Ayse FilizCitak, AgopSik, GuntuluBingol, IbrahimAygun, FatihDurak, CansuYilmaz, ResulBugrul, FuatSari, YusufTekguc, HakanAlbayrak, HaticeYener, NazikAgin, HasanSoydan, EkinYildizdas, DincerDilek, Semine OzdemirYalindag, NiluferIncekoy-Girgin, FeyzaAlacakir, NuriTutunculer, FilizArslanaoglu, Mehmet OzgurAydin, CanBilgin, MuzafferSimsek, EnverDinleyici, Ener Cagri2023-02-212023-02-212022-01-0110.3389/fped.2022.926013https://hdl.handle.net/11443/2805http://dx.doi.org/10.3389/fped.2022.926013IntroductionThere have been some significant changes regarding healthcare utilization during the COVID-19 pandemic. Majority of the reports about the impact of the COVID-19 pandemic on diabetes care are from the first wave of the pandemic. We aim to evaluate the potential effects of the COVID-19 pandemic on the severity of diabetic ketoacidosis (DKA) and new onset Type 1 diabetes presenting with DKA, and also evaluate children with DKA and acute COVID-19 infection. MethodsThis is a retrospective multi-center study among 997 children and adolescents with type 1 diabetes who were admitted with DKA to 27 pediatric intensive care units in Turkey between the first year of pandemic and pre-pandemic year. ResultsThe percentage of children with new-onset Type 1 diabetes presenting with DKA was higher during the COVID-19 pandemic (p < 0.0001). The incidence of severe DKA was also higher during the COVID-19 pandemic (p < 0.0001) and also higher among children with new onset Type 1 diabetes (p < 0.0001). HbA1c levels, duration of insulin infusion, and length of PICU stay were significantly higher/longer during the pandemic period. Eleven patients tested positive for SARS-CoV-2, eight were positive for new onset Type 1 diabetes, and nine tested positive for severe DKA at admission. DiscussionThe frequency of new onset of Type 1 diabetes and severe cases among children with DKA during the first year of the COVID-19 pandemic. Furthermore, the cause of the increased severe presentation might be related to restrictions related to the pandemichowever, need to evaluate the potential effects of SARS-CoV-2 on the increased percentage of new onset Type 1 diabetes.COVID-19childrendiabetesdiabetic ketoacidosispandemicpediatric intensive care unitArticleWOS:000826479900001