Degertekin, BulentTozun, NurdanDemir, FigenSoylemez, GizemParkan, SirinGurtay, EzgiMutlu, DenizToraman, MeltemSeymenoglu, Tolga Hayrettin2023-02-212023-02-212021-01-0110.5152/tjg.2021.20062https://hdl.handle.net/11443/1103http://dx.doi.org/10.5152/tjg.2021.20062Background: The true prevalence of non-alcoholic fatty liver disease (NAFLD) is unknown in Turkey due to a lack of population-based studies. The aim of this study was (i) to determine the overall and region-specific prevalence of NAFLD in Turkey(ii) to analyze the factors associated with the prevalenceand (iii) to determine the nationwide change in the prevalence of NAFLD in the last decade. Methods: The 10-year data (2007-2016) of 113 239 apparently healthy subjects visiting the check-up clinics of Acibadem Hospitals Group were retrospectively analyzed. A subgroup of patients (n=8120) statistically representing the bigger cohort was selected. The prevalence was analyzed according to ultrasound findings, age, sex, body mass index (BMI), geographical region, and time periods trisected as 2007-2010, 2011-2013, and 2014-2016. Results: The overall prevalence of NAFLD in Turkey was found to be 48.3\%. It was highest among people >50 years of age (65.6\%), male sex (64.0\%), with a BMI>25 kg/m(2) (63.5\%), and in Central and Eastern Anatolia regions (57.1\% and 55.7\%, respectively). The prevalence of NAFLD was 43.5\% between 2007 and 2010, 47.6\% between 2011 and 2013, and 53.1\% between 2014 and 2016, and the rate of increase was 22\%. Multivariate analysis showed that male sex serum alanine aminotransferase level, older age, BMI, type-II diabetes mellitus, hypertension, and dyslipidemia were independent factors associated with NAFLD. Conclusion: NAFLD is a highly prevalent disease affecting almost half of the Turkish population (48.3\%). We are faced with a dramatic increase in NAFLD prevalence in the past 10 years.Fatty livernon alcoholic fatty liverprevalenceTurkeyobesityArticleWOS:000667494100009