Demirbilek, HuseyinBacak, GokhanBaran, Riza TanerAvci, YahyaBaran, AhmetKeles, AysenurOzbek, Mehmet NuriAlanay, YaseminHussain, Khalid2023-02-212023-02-212014-01-0110.4274/jcrpe.1477https://hdl.handle.net/11443/2550http://dx.doi.org/10.4274/jcrpe.1477Prepubertal unilateral gynecomastia is an extremely rare condition. At present, its etiology and management strategy are not well known. Two unrelated prepubertal boys of ages 8 and 9 who presented with complaints of unilateral enlargement of breast tissue are reported. Physical examination, biochemical, hormonal and oncologic work-up findings were normal. Both patients were treated with peripheral liposuction successfully. Histopathological and immunohistochemical examinations showed benign fibroglandular gynecomastia and intensive (3+) estrogen receptor expression in 100\% of periductal epithelial cells. Although an extremely rare and generally benign condition, patients with prepubertal unilateral gynecomastia should have a full endocrine and oncologic work-up.GynecomastiapubertalprepubertalunilateralArticleWOS:000347785700009