Atsu, Ayse NilhanBilgic, TayfunKayhan, Cavit KeremSaglam, Zumrut Mine IsikCaf, Nazli2023-02-212023-02-212022-01-0110.5472/marumj.1186858https://hdl.handle.net/11443/2256http://dx.doi.org/10.5472/marumj.1186858Objective: St. John's wort (SJW) oil (Hypericum perforatum) has been used for its immunomodulatory and anti-inflammatory effects. Several studies have shown the efficacy of SJW on wound healing. The aim of this study is to assess the effectiveness of SJW using a combination of biochemical, histopathological and laser Doppler evaluations. Materials and Methods: Sixteen young Wistar albino rats were used as case and control groups (having 8 in each group). After anesthesia protocol, 6 mm punch biopsy was taken from six separate sites on the rats' dorsal skin. Three wounds were stitched (closed wounds)three wounds were left as they were (open wounds). SJW oil was administered topically to case group once a day for 14 days. Controls did not receive any treatment. Results: There was no statistical difference in blood perfusion between the groups. No statistical difference was present between the groups in GPx (glutathionc peroxidase)valucs. Rat MDA (malonyldialdehydc) values were higher in the case group compared to the control group. SJW oil was found to be beneficial and effective within some histological parameters. Conclusion: SJW may be an effective salve within some parameters. Nevertheless, this judgment is uncertain due to the low sample size. We encourage further studies on this promising natural medicine.Antiinflammatoryfibroblastglutathionc peroxidaseSt. John's wortwoundArticleWOS:000878860500002