Naki, M. MuratOran, GulbinTetikkurt, Seza UmitSonmez, Cavide FatmaTurkmen, IlknurKose, Faruk2023-02-212023-02-212017-01-0110.4274/jtgga.2017.0016https://hdl.handle.net/11443/2108http://dx.doi.org/10.4274/jtgga.2017.0016Objective: To investigate the association of microcystic, elongated, and fragmented (MELF) pattern of invasion with prognostic factors in endometrioid endometrial adenocarcinoma (EEA). Material and Methods: Stained tissue sections from 83 cases of EEA operated by the same gynecologic oncologist were reviewed to identify cases showing MELF-type invasion in this retrospective study. The association of MELF pattern with age, tumor grade, depth of myometrial invasion, and presence of lymphovascular space invasion (LVSI) was analyzed. Results: FIGO grade 2 and grade 1 tumors were evident in 53.0\% and 38.6\% of patients, respectively. Depth of myometrial invasion was <50\% in 72.0\% of patients, and LVSI was absent in 77.1\%. MELF pattern was confirmed in 35 (42.2\%) patients. Presence of MELF pattern was associated with significantly higher mean +/- standard deviation age (62.9 +/- 6.9) years vs. 58.9 +/- 9.1 years, p=0.033), and found to be more likely in patients with high-grade tumor (FIGO grade III85.7\% vs. 14.3\%, p<0.001), deep (>= 50\%) myometrial invasion (78.3\% vs. 21.7\%, p<0.001), and presence of LVSI (94.7\% vs. 5.3\%, p<0.001) as compared with absence of MELF pattern. Conclusion: In conclusion, our findings revealed a high rate of MELF pattern among patients with EEA alongside the association of MELF pattern with poor prognostic factors such as high grade tumor, deep myometrial invasion, and LVSI.Endometrioid endometrial adenocarcinomamicrocysticelongatedfragmented patterntumor grademyometrial invasionlymphovascular space invasionArticleWOS:000423954800008