Cabioglu, NeslihanGuerdal, Sibel OEzkanKayhan, ArdaOEzaydin, NilueferSahin, CennetCan, OEmuerOEzcinar, BeyzaAykuter, GoenuelVatandas, GuelcinAribal, ErkinOEzmen, Vahit2023-02-212023-02-212020-01-0110.1200/GO.20.00145https://hdl.handle.net/11443/2472http://dx.doi.org/10.1200/GO.20.00145PURPOSE The Turkish Bahceehir Breast Cancer Screening Project was a 10-year, organized, population-based screening program carried out in Bahceehir county, Istanbul. Our aim was to examine the biologic features and outcome of screen-detected and interval breast cancers during the 10-year study period. METHODS Between 2009 and 2019, 2-view mammograms were obtained at 2-year intervals for women aged 40 to 69 years. Clinicopathological characteristics including ER, PR, HER2-neu, and Ki-67 status were analyzed for those diagnosed with breast cancer. RESULTS In 8,758 screened women, 131 breast cancers (1.5\%) were detected. The majority of patients (82.3\%) had prognostic stage 0-I disease. Contrarily, patients with interval cancers (n = 1511.4\%) were more likely to have a worse prognostic stage (II-IV diseaseodds ratio {[}OR], 3.59, 95\% CI, 0.9 to 14.5) and high Ki-67 scores (OR, 3.1495\% CI, 0.9 to 11.2). Interval cancers detected within 1 year were more likely to have a luminal B (57.1\% v 31.9\%) and triple-negative (14.3\% v 1\%) subtype and less likely to have a luminal A subtype (28.6\% v 61.5\%P = .04). Patients with interval cancers had a poor outcome in 10-year disease-specific (DSS) and disease-free survival (DFS) compared with those with screen-detected cancers (DSS: 68.2\% v 98.1\%, P = .002DFS: 78.6\% v 96.5\%, P = .011). CONCLUSION Our findings suggest the majority of screen-detected breast cancers exhibited a luminal A subtype profile with an excellent prognosis. However, interval cancers were more likely to have aggressive subtypes such as luminal B subtype or triple-negative cancers associated with a poor prognosis requiring other preventive strategies. (c) 2020 by American Society of Clinical OncologyArticleWOS:000564861600023