Yuksel, Sirin KilicturgayOzduman, KorayYilmaz, EnginPamir, M. NecmettinAkyerli, Cemaliye B.2023-02-212023-02-212021-01-0110.5137/1019-5149.JTN.29805-20.2https://hdl.handle.net/11443/1049http://dx.doi.org/10.5137/1019-5149.JTN.29805-20.2AIM: To investigate the effect of mitochondrial DNA (mtDNA) variants mainly in D-loop on glioma biology. MATERIAL and METHODS: Sanger sequencing of D-loop (15971-16451 bp) for 52 glioma patients was performed and the variations were statistically analyzed for gender, WHO classification, morphological grade, IDH/TERT status. RESULTS: Total of 122 variations (51 unique) were identified in 52 patients. C16223T, T16189C, T16311C and T16126C variants were frequently detected. The total variation number was statistically non-significant among the analyzed categories. When individual variants were considered, T16311C and T16224C were statistically significant for WHO classification (p=0.033), morphological grade (p=0.036) and gender (p=0.039), respectively. CONCLUSION: Total variation number in D-loop was not found to be related with clinical variables. Our data suggests that individual variants may play a critical role in glioma biology.D-loopGliomaMitochondrial DNAmtDNA variationsMutationsArticleWOS:000650214600010