Acıbadem Üniversitesi

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Acıbadem Sağlık Bilimleri Dergisi
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Recent Submissions

The greater sciatic notch-based transcolumnar magic screw trajectory in the acetabulum: An anatomical guide
(TURKISH JOINT DISEASES FOUNDATION, 2026)
Ismailoglu, Pelin
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Kazdal, Cengiz
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Uysal, Emrehan
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Bayramoglu, Alp
Objectives: This study aims to define the greater sciatic notch (GSN)-based transcolumnar magic screw corridor in the acetabulum and to assess its morphometric characteristics and anatomical feasibility according to quadrilateral plate (QP) morphology. Materials and methods: Between November 2025 and January 2026, three-dimensional morphometric analysis was performed on pelvic CT reconstructions of 90 adults (180 acetabulae) with intact pelvic bones and no evidence of hip or pelvic pathology. Using Mimics, pelvic models were reconstructed and a virtual 6.5-mm cannulated screw was advanced from the midpoint of the GSN toward the anterior column along a transcolumnar intraosseous trajectory. Bilateral trajectory length, angulation, and QP thickness were recorded. Differences by sex and side, age associations, and anatomical feasibility (easy versus hard) were analyzed based on anatomical corridor constraints. Results: Of the patients included in the study, 42 were male and 48 were female with a mean age of 49.88 +/- 17.18 (range, 19 to 86) years. The defined GSN-based transcolumnar screw corridor was anatomically feasible in 94.44% of cases. Mean posterior acetabular screw length was 74.16 +/- 7.49 mm right and 73.21 +/- 6.90 mm left. Mean GSN entry segment length was 22.95 +/- 4.14 mm right and 23.48 +/- 4.34 mm left. Mean acetabular screw angles were 125.86 +/- 6.05 degrees right and 124.26 +/- 5.24 degrees left, with a small but significant right-left difference (p = 0.004). The QP morphology demonstrated substantial variability: mean maximum thickness was 14.87 +/- 2.75 mm right and 14.77 +/- 2.82 mm left, while minimum thickness was 3.46 +/- 1.37 mm right and 3.48 +/- 1.32 mm left. Men had significantly greater superior and posterior acetabular screw lengths and markedly thicker QP parameters compared with women (all p <= 0.027), with large effect sizes for QP thickness (d > 1.0). Conclusion: A GSN-based transcolumnar magic screw corridor appears anatomically feasible in most adult pelves and provides a quantifiable intraosseous trajectory reaching both acetabular columns. Quadrilateral plate thickness emerges as the main anatomical limiting factor, particularly in female pelves and in cases categorized as corridor-constrained.
Whole-Brain Structural Connectivity Alterations in Chronic Subjective Tinnitus: An Exploratory Diffusion Tensor Imaging Study
(MDPI, 2026)
Elpen Karyemez, Pinar
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Ulus, Sila
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Yilmaz, Eren
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Yildirim, Duzgun
Background/Objectives: Subjective tinnitus, the underlying mechanism of which remains largely unknown, accounts for the majority of cases. Although conventional MRI and audiometric assessments demonstrate limited effectiveness in identifying organic causes, advanced microstructural techniques-such as diffusion tensor imaging (DTI) and fiber tractography-facilitate the evaluation of microanatomical connectivity related to auditory processing. This study employed DTI to examine alterations in microanatomical brain connectivity in patients with chronic subjective tinnitus, in comparison to a healthy control group. Methods: This study performed a comparative analysis of whole-brain connectivity maps, derived from Diffusion Tensor Imaging, between 47 patients with chronic subjective tinnitus (symptom duration >= 2 years) and 42 healthy controls. To ensure a robust assessment of micro-anatomical neural connectivity, DTI datasets were processed using the DSI Studio platform, with anatomical regions systematically mapped using automatic anatomical labeling atlases. Specifically, these metrics were evaluated across nodes in the central auditory pathway and limbic system to identify potential disruptions in structural integrity. Results: The comparative analysis revealed significant micro-anatomical connectivity alterations in patients with chronic subjective tinnitus. Changes in structural integrity were observed predominantly across key nodes within the central auditory pathway and limbic system, specifically involving the frontal, submarginal, cingular, insular, parietal, precuneus, cuneus, amygdala, thalamus, supplementary motor area, and precentral regions. Conclusions: Chronic subjective tinnitus was associated with a distinct, largely asymmetrical pattern of whole-brain structural connectivity, predominantly involving nodes of the salience, default-mode, and central-executive networks. Because behavioral, audiometric, and cognitive measures were not acquired, these findings are exploratory and hypothesis-generating; their cognitive and occupational relevance will require confirmation in studies that combine connectivity mapping with direct behavioral and audiological testing.
Mood Disorders and Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis
(MDPI, 2026)
Yesiloglu, Buket
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Yesilkaya, Umit Haluk
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Bengi, Deniz
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Sen, Meltem
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Ozgunduz, Ceren Meric
Background/Objectives: Mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BD), along with obstructive sleep apnea (OSA), are prevalent conditions that have serious effects on affected individuals and public health. These issues have received more attention recently, as research shows there are similar risk factors and they can influence each other by worsening symptoms and treatment response. However, there is still no clear understanding of the extent of this co-occurrence and the factors that influence it. Methods: A systematic review of comorbid OSA and mood disorders was conducted from EMBASE, Ovid MEDLINE, Global Health, and APA PsycINFO (1 January 2013-25 July 2025), with meta-analyses applying random-effects models in R (metafor). Heterogeneity, publication bias, subgroup effects, and meta-regression analyses were performed by assessing demographic, clinical, and study quality variables. Results: Out of 6221 screened studies, 23 articles met eligibility criteria, yielding 2,380,986 OSA patients, with 446,495 comorbid mood disorders (MDD = 446,290; BD = 205), and 5724 mood disorder patients (MDD = 1987; BD = 3737) with 450 comorbid OSA. All meta-analyses demonstrated a significant prevalence of comorbidity, accompanied by substantial heterogeneity. Meta-regression analyses identified mean age (beta = 0.18, 95% CI 0.03-0.33, p = 0.02) and mean body mass index (beta = -0.18, 95% CI -0.32 to -0.04, p = 0.01) as significant moderators of OSA prevalence. Conclusions: This meta-analysis indicates a high prevalence of comorbidity between OSA and mood disorders, including MDD and BD, with significant heterogeneity. Age and body mass index emerged as significant moderators of OSA prevalence, emphasizing the need for systematic screening and tailored approaches in both clinical practice and research.
Food inflation, nutrition behavior, food insecurity, and anxiety: a Bayesian network analysis among Turkish adults
(FRONTIERS MEDIA SA, 2026)
Ongun Yilmaz, Hande
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Arslan, Sedat
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Yilmaz, Salim
Background Food inflation is a pervasive economic stressor that may disrupt nutritional behaviors and amplify food insecurity, yet the complex pathways linking these phenomena to psychological distress remain poorly understood. This study aimed to map the conditional dependency structure among food inflation-related behavioral changes, food insecurity, and anxiety in Turkish adults using Bayesian Network analysis.Methods A cross-sectional online survey was conducted among 1,042 Turkish adults (72.9% female; 57.0% aged 18-24) between November and December 2025. The Effect of Food Inflation on Nutrition Behavior (EFINUB), The Impact of Food Inflation on Consumer Behavior (IFI-ConB), Food Insecurity Experience Scale, and Beck Anxiety Inventory were administered alongside sociodemographic measures. A Conditional Gaussian Bayesian Network with 23 nodes was learned using bootstrap-averaged structure learning (1,000 resamples, strength threshold >= 0.85), followed by Markov blanket analysis, conditional probability queries, and what-if policy simulations.Results The network revealed 25 directed arcs organized into three isolated clusters: demographic, dietary habits, and scale-relationship. Food insecurity emerged as the sole member of the anxiety Markov blanket. Severe food insecurity rose from 1.2% to 48.2% (an absolute increase of 47.0 percentage points) across Low to High Food Consumption Impact groups. Simulating universal food security produced the largest anxiety reduction (-61.0%), whereas partial behavioral improvement reduced food insecurity but not anxiety. Sensitivity analyses confirmed structural robustness across threshold specifications (29 arcs at 0.70) and gender-balanced resampling (Jaccard = 0.808).Conclusion Food insecurity is the primary conduit through which food inflation-related behavioral disruptions translate into anxiety. Policy responses may benefit from prioritizing direct food security support over partial behavioral assistance when the goal is to reduce anxiety burden.
Reply to The question of whether narcolepsy increases mortality should be answered based on reliable studies
(SPRINGER INT PUBL AG, 2026)
Sharafkhaneh, Amir
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BaHammam, Ahmed S.
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Dauvilliers, Yves
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Azarian, Mehnaz
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Thorpy, Michael