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Item type:Yayın, The Role of Glial Cells in the Pathophysiology of Epilepsy(MDPI, 2025-01-10) Filiz Onat; My Andersson; Nihan ÇarçakEpilepsy is a chronic neurological disorder marked by recurrent seizures, significantly impacting individuals worldwide. Current treatments are often ineffective for a third of patients and can cause severe side effects, necessitating new therapeutic approaches. Glial cells, particularly astrocytes, microglia, and oligodendrocytes, are emerging as crucial targets in epilepsy management. Astrocytes regulate neuronal homeostasis, excitability, and synaptic plasticity, playing key roles in maintaining the blood–brain barrier (BBB) and mediating neuroinflammatory responses. Dysregulated astrocyte functions, such as reactive astrogliosis, can lead to abnormal neuronal activity and seizure generation. They release gliotransmitters, cytokines, and chemokines that may exacerbate or mitigate seizures. Microglia, the innate immune cells of the CNS, contribute to neuroinflammation, glutamate excitotoxicity, and the balance between excitatory and inhibitory neurotransmission, underscoring their dual role in seizure promotion and protection. Meanwhile, oligodendrocytes, primarily involved in myelination, also modulate axonal excitability and contribute to the neuron–glia network underlying seizure pathogenesis. Understanding the dynamic interactions of glial cells with neurons provides promising avenues for novel epilepsy therapies. Targeting these cells may lead to improved seizure control and better clinical outcomes, offering hope for patients with refractory epilepsy.Item type:Yayın, Enhancing Research Support Services Through an EU Project: A Case Study(SSRN, 2025-07-25) Melike Şahiner; Oğuzhan Altınkoz; Eda Tanoğlu; Filiz OnatItem type:Yayın, WONOEP appraisal: Targeted therapy development for early onset epilepsies(Wiley, 2024-11-19) Pablo M. Casillas-Espinosa; Jennifer C. Wong; Wanda Grabon; Ana Gonzalez-Ramos; Massimo Mantegazza; Nihan Carcak Yilmaz; Manisha Patel; Kevin Staley; Raman Sankar; Terence J. O'Brien; Özlem Akman; Ganna Balagura; Adam L. Numis; Jeffrey L. Noebels; Stéphanie Baulac; Stéphane Auvin; David C. Henshall; Aristea S. GalanopoulouItem type:Yayın, GEMSTONE Research Data: Investigation of OX2R Distribution by Immunofluorescence(Acıbadem Mehmet Ali Aydınlar University Publications, 2025-12-27) Mutlu, Nursima; Açıkel Elmas, Merve; Sevinç Özdemir, Neval; Turan, Talat Taygun; Çavuş, Merve; Çarçak Yılmaz, Nihan; Onat, FilizItem type:Yayın, GEMSTONE Research Data: EEG Recordings from Chemogenetic Applications on Mice(Acıbadem Mehmet Ali Aydınlar University Publications, 2025-12-29) Çarçak Yılmaz, Nihan; Çavuş, Merve; Mutlu, Nursima; Onat, Filiz
