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Neurodevelopmental Alterations in Inhibitory Interneurons of Cortex, Hippocampus, and Striatum of Genetic Absence Epilepsy Rats
(Wiley, 2026-08-19) Çarçak, Nihan; Erdeve, Elif Tuğçe; Wright, Courtney J.; Keskinöz, Elif; Anderson, My; Onat, Filiz; Kırık, Deniz
Aims Absence seizures, characterized by spike-and-wave discharges (SWDs), are mediated by reciprocal thalamocortical interactions; however, the contribution of developing inhibitory networks to SWDs remains unclear. We investigated the developmental trajectory of inhibitory interneurons in Genetic Absence Epilepsy Rats from Strasbourg (GAERS) by analyzing their distribution across postnatal development in the somatosensory (S1) and motor (M1) cortices, the hippocampus, and striatum. Methods The neurodevelopmental trajectory of parvalbumin-positive (PV+) and somatostatin-positive (SST+) interneurons was quantified at three critical stages: postnatal day 14 (P14), when SWDs were not yet observed, P21 when immature SWDs appear, and adulthood (P90), when mature SWDs are established. Wistar rats served as controls. Brain sections were processed immunohistochemically to quantify interneuron density. Results PV+ interneuron density across S1 and M1 was significantly higher in GAERS at P14 than control. However, this difference was not maintained at P21 and adults. Conversely, SST+ interneurons exhibited a delayed increase in M1. GAERS displayed higher PV+ interneuron density in the dentate gyrus and CA1 at P14, whereas SST+ interneuron density remained unchanged across hippocampal subfields. Striatal PV+ and SST+ interneurons increased at later developmental stages, suggesting altered inhibition in basal ganglia. Conclusion These findings demonstrate a temporally dynamic and region-specific reorganization of interneurons in GAERS that may underlie absence epileptogenesis.
Timing Of MRI in Acute Lateral Ankle Sprain: Impact On Diagnostic Findings And Clinical Interpretation – A Retrospective Observational Cohort Study
(Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 2026-08-03) Özbay, Hakan; Alpan, Buğra
Background: This study aimed to investigate the impact of magnetic resonance imaging (MRI) timing on radiological findings and diagnostic interpretability in patients with acute lateral ankle sprain. Methods: In this retrospective observational cohort study, 75 adult patients with acute inversion-type ankle sprain were divided into three equal groups based on MRI timing: hyperacute (0–7 days), subacute (8–21 days), and late (>21 days). All MRIs were performed using a 3.0T scanner and evaluated by a blinded musculoskeletal radiologist. Ligament integrity, bone marrow edema, joint effusion, and soft tissue edema were assessed, along with a 3-point diagnostic interpretability scale. Multivariate analyses adjusted for age, sex, and clinical severity. Results: ATFL tear classification differed significantly across groups (p<0.05), with higher rates of complete tears in the hyperacute group. Bone marrow edema and joint effusion were most pronounced in early imaging and progressively decreased over time (p<0.05). Diagnostic interpretability was lowest in the hyperacute group and highest in the subacute group (p<0.05). MRI timing remained an independent predictor of ligament injury classification and edema visibility after adjustment. Conclusion: MRI timing significantly influences both the radiological appearance and interpretability of acute lateral ankle sprain. Subacute imaging appears to provide the most balanced diagnostic clarity, suggesting that MRI should be optimally timed based on clinical objectives. Trial registration: Not applicable (retrospective study)
6 Şubat 2023 depremi sonrası yaşanan ilaca erişim sorununun biyoetik açıdan değerlendirilmesi
(Acıbadem Mehmet Ali Aydınlar Üniversitesi, 2024-01-01) Bayram, Dilara Özgür; dan. Yeşim Işıl Ülman
Development and efficacy of a novel monoclonal antibody targeting CX3CR1 for pain relief in pancreatic cancer and chronic pancreatitis
(Acıbadem Mehmet Ali Aydınlar Üniversitesi, 2024-01-01) Baybağ, Deniz; supervisor Güralp Onur Ceyhan
Memenin duktal karsinoma in situ olgularında moleküler subtiplere göre manyetik rezonans görüntüleme bulgularında fark var mıdır ?
(Acıbadem Mehmet Ali Aydınlar Üniversitesi, 2025-01-01) Ilhanoğlu, Amelya Zeynalova; dan. Selma Gül İçten