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    Computational Insights from ERAP1 and ERAP2 Variants for the Pathogenesis of Ankylosing Spondylitis
    (Acıbadem Mehmet Ali Aydınlar Üniversitesi, 2022-01-01) Dilek, Yunus Emre
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    Geriatric Syndromes in Polymyalgia Rheumatica: A Cross-Sectional Study
    (Acıbadem Mehmet Ali Aydınlar Üniversitesi, 2025-07-01) Mert Oztas; Veysel Suzan
    Abstract Background/Purpose: Polymyalgia rheumatica (PMR) is a common inflammatory disorder in the elderly. Geriatric syndromes as losses in activities of daily living, fraility, nutritional deficits and sarcopenia were conditions that become increasingly prevalent with age. Whilist PMR is a disease mostly affects geriatric population, there is a scarce data about PMR and possible accompanying geriatric syndromes. We examined prevalence of the accompanying geriatric syndromes in PMR patients and compare with age (±<5years) and sex matched controls. Methods: Ten patients (8 female/2 male) diagnosed with PMR according to ACR/EULAR 2012 provisional PMR criteria and ten healthy controls were included to present study. Losses in activities of daily living was evaluated with Activities of Daily Living (ADLs) and Instrumental Activities of Daily Living (IADLs) Nutritional status were assessed with Mini-Nutritional Assessment Short Form. Muscle strength evaluated with hand grip test. Patients with lowered muscle strength were labeled as probable sarcopenia according to The European Working Group on Sarcopenia in Older People (EWGSOP2) 2018. Results: The mean age was 75±7,9 for patients and 75,7±7,9 6,6 for controls (p=0.9). Mean hand grip strength was significantly lower in PMR patients (p=0.04) and probable sarcopenia was strikingly more common in patient group (p=0.01). Difference between the groups in terms of activities of daily living, nutritional status was non-significant. Conclusion: Higher prevalence of sarcopenia was disclosed at immune mediated rheumatic disease patients in the previous studies. Current study indicates that PMR patients were significantly more prone to probable sarcopenia. Further efforts are needed to ameliorate the patients’ care, quality of life and well-being.
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    Value of Repeated Transurethral Resection in Superficial Bladder Cancer
    (Acıbadem Mehmet Ali Aydınlar Üniversitesi, 2025-01-01) Hakan Cakir; Numan Dogu Guner; Turgut Alp; M. İhsan Karaman
    Abstract Background: Bladder cancer is a prevalent malignancy of the urinary system, with superficial tumors representing the majority of cases. Despite initial treatment with transurethral resection (TUR), these tumors have high recurrence rates (70-80%) and can progress to muscle-invasive disease in 20-30% of cases. Repeat transurethral resection (re-TUR) has been proposed as a method to improve staging accuracy and reduce the likelihood of recurrence by detecting residual tumor tissue. Methods: This prospective study included 100 patients with superficial bladder cancer (Ta and T1 stages) treated at the Urology Clinic of Istanbul Fatih Sultan Mehmet Training and Research Hospital between January 2005 and December 2006. Following the initial TUR, all patients underwent re-TUR within 4 to 6 weeks. Pathological findings from both procedures were analyzed to identify residual tumor presence and changes in tumor stage. Patients were followed up for 24 months to monitor recurrence rates and progression to muscle-invasive disease. Results: Re-TUR revealed residual tumor tissue in 40% of patients, with higher detection rates in T1 and Grade II tumors. Patients with residual tumors had a significantly higher recurrence rate (40%) compared to those without residual tumors (15%). Additionally, 20% of patients with residual tumors progressed to muscle-invasive bladder cancer, while no progression was observed in patients without residual tumors. Conclusion: Re-TUR plays a vital role in improving staging accuracy and reducing recurrence in patients with superficial bladder cancer. The presence of residual tumors significantly increases the risk of recurrence and progression, highlighting the importance of re-TUR, especially in high-risk patients. These findings support the routine use of re-TUR in managing superficial bladder cancer.

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