786T/c endothelial nitric oxide synthase gene polymorphism and coronary collateral circulation
786T/c endothelial nitric oxide synthase gene polymorphism and coronary collateral circulation
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Tarih
2016-01-01
Yazarlar
Seckin, Satilmis
Emrah, Bozbeyoglu
Biyik, Ismail
Emre, Arugaslan
Burak, Tangurek
Azmi, Sungur
Omer, Celik
Sinan, Dagdelen
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
Yayınevi
POLISH ACAD SCIENCES, INST IMMUNOL \& EXP THERAPY
Dergi Adı
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ
Özet
Introduction: In this study, we investigated the association between -786T/C polymorphism of the endothelial nitric oxide (NOS3) gene in which thymidine is replaced by a cytosine at nucleotide -786 (rs 2070744) and coronary collateral circulation (CCC) in patients with stable coronary artery disease. Materials \& Methods: 286 patients having a critical stenosis (> 95\%) in at least one major epicardial coronary vessel were included in the study. CCC was defined according to the Rentrop classification (R). Patients with R0-1 CCC were included in the poor CCC group and subjects with R2-3 CCC were assigned to the good CCC group. The polymerase chain reaction method was used for genotyping. 152 patients with poor CCC and 134 patients with good CCC were examined. Results: The frequency of cytosine-cytosine (CC) and thymidine-cytosine (TC) genotypes and allele C were higher in the poor CCC group, but the difference did not reach statistical significance. In the dominant model, the frequency of CC+TC vs. thymidine-thymidine (TT) genotypes was significantly higher in the poor CCC group (67.1\% vs. 54.5\%, respectively
chi(2)=4.78
p=0.02). In multivariate regression analysis, the dominant model for -786T/C polymorphism of the NOS3 gene remained as an independent correlate of poor CCC. Discussion: -786T/C polymorphism of the NOS3 gene (rs 2070744) may be associated with poor angiogenesis and the development of CCC in stable coronary artery disease.
chi(2)=4.78
p=0.02). In multivariate regression analysis, the dominant model for -786T/C polymorphism of the NOS3 gene remained as an independent correlate of poor CCC. Discussion: -786T/C polymorphism of the NOS3 gene (rs 2070744) may be associated with poor angiogenesis and the development of CCC in stable coronary artery disease.
Açıklama
Anahtar kelimeler
coronary collateral circulation, nitric oxide, eNOS gene polymorphism