Magnetic Resonance Image-Guided Hypofractionated Ablative Radiation Therapy for Hepatocellular Carcinoma With Tumor Thrombus Extending to the Right Atrium

dc.contributor.authorDincer, Neris
dc.contributor.authorUgurluer, Gamze
dc.contributor.authorMustafayev, Teuta Zoto
dc.contributor.authorGungor, Gorkem
dc.contributor.authorAtalar, Banu
dc.contributor.authorGuven, Koray
dc.contributor.authorOzyar, Enis
dc.date.accessioned2023-02-21T12:34:10Z
dc.date.available2023-02-21T12:34:10Z
dc.date.issued2022-01-01
dc.description.abstractHepatocellular carcinoma (HCC) presenting with tumor thrombus and inferior vena cave (IVC)/right atrium (RA) infringement point to an advanced-stage disease that is deemed inoperable. Stereotactic body radiotherapy is an emerging treatment option for this group of patients with promising outcomes in recent studies that are comparable to conventional treatment methods, namely, transarterial chemoembolization and transarterial radioembolization. Here, we report a case of HCC with RA extension through the IVC. The patient was referred to our clinic for treatment options, and he was found suitable for magnetic resonance imaging-guided radiotherapy (MRgRT). We treated the patient with MRgRT in five fractions to a total dose of 40 Gray. The tumor was tracked during the treatment sessions, and adaptive treatment planning was performed before each fraction. The patient tolerated the treatment well with no acute grade 3-4 toxicities. The last follow-up showed that the patient had a complete biochemical response and is now a candidate for an orthotopic liver transplant. To our knowledge, this report is the first to document the MRgRT treatment of an HCC with TT and RA extension. MRgRT is safe and feasible for this patient group and can be an effective bridging therapy for liver transplants.
dc.description.issue4
dc.description.issueAPR 9
dc.description.volume14
dc.identifier.doi10.7759/cureus.23981
dc.identifier.urihttps://hdl.handle.net/11443/1681
dc.identifier.urihttp://dx.doi.org/10.7759/cureus.23981
dc.identifier.wosWOS:000787895700027
dc.publisherCUREUS INC
dc.relation.ispartofCUREUS JOURNAL OF MEDICAL SCIENCE
dc.subjectmr-linac
dc.subjectsbrt
dc.subjecttumor thrombus
dc.subjectinoperable
dc.subjecthepatocellular cancer
dc.titleMagnetic Resonance Image-Guided Hypofractionated Ablative Radiation Therapy for Hepatocellular Carcinoma With Tumor Thrombus Extending to the Right Atrium
dc.typeArticle

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