Human papillomavirus prevalence and type in liquid-based cervical samples from Turkish women in a selected risk group

dc.contributor.authorAkyar, Ism
dc.contributor.authorAydin, Ozlem
dc.contributor.authorYakicier, Mustafa Cengiz
dc.contributor.authorKocagoz, Zuhtu Taml
dc.contributor.authorInce, Umit
dc.contributor.authorUnsal, Ibrahim
dc.date.accessioned2023-02-21T12:32:16Z
dc.date.available2023-02-21T12:32:16Z
dc.date.issued2013-01-01
dc.description.abstractAim: To detect the prevalence and type distribution of human papillomavirus (HPV) in different cytological diagnostic categories. Materials and methods: Between 2007 and 2010, a total of 1014 liquid-based thin preparations of cervical smears were selected and classified according to cytology results. HPV DNA polymerase chain reaction (PCR) was also performed using these samples. HPV DNA-positive samples were genotyped by DNA sequencing. Results: Of those enrolled in the study, 45.3\% were negative cytologically, 36.4\% had atypical squamous cells of undetermined significance, 0.3\% had atypical squamous cells preventing the exclusion of a high-grade squamous intraepithelial lesion, 16.8\% showed a low-grade squamous intraepithelial lesion, and 1.3\% had an high-grade squamous intraepithelial lesion. Conclusion: PCR assays showed HPV positivity in 63.0\% of cytologically negative and 90.8\% of cytologically positive samples. The most common types of HPV detected were 16, 6, 18, 31, 66, 56, 53, 81, 45, and 62. Of HPV DNA-positive samples, 47.7\% were high, 4.7\% were intermediate, and 17.9\% were low risk. The high-risk types of HPV detected were 16, 18, 31, 56, 53, 45, 62, 58, 59, 67, 51, 35, 73, 52, 33, 39, 68, and 82.
dc.description.issue6
dc.description.pages963-970
dc.description.volume43
dc.identifier.doi10.3906/sag-1211-67
dc.identifier.urihttps://hdl.handle.net/11443/942
dc.identifier.urihttp://dx.doi.org/10.3906/sag-1211-67
dc.identifier.wosWOS:000325156700015
dc.publisherTUBITAK SCIENTIFIC \& TECHNICAL RESEARCH COUNCIL TURKEY
dc.relation.ispartofTURKISH JOURNAL OF MEDICAL SCIENCES
dc.subjectCytology
dc.subjecthuman papillomavirus DNA
dc.subjectgenotype
dc.subjectpolymerase chain reaction
dc.titleHuman papillomavirus prevalence and type in liquid-based cervical samples from Turkish women in a selected risk group
dc.typeArticle

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