The Impact and Prognostic Significance of Chronic Lymphocytic Leukemia Upregulated 1 (CLLU1) Gene Expression in Patients with Chronic Lymphocytic Leukemia: A Single Center Experience
dc.contributor.author | Sevinc, Mustafa | |
dc.contributor.author | Karabulut, Aydin | |
dc.contributor.author | Eskazan, Ahmet Emre | |
dc.contributor.author | Tatonyan, Suzin Catal | |
dc.contributor.author | Ozbek, Ugur | |
dc.contributor.author | Soysal, Teoman | |
dc.date.accessioned | 2023-02-21T12:37:49Z | |
dc.date.available | 2023-02-21T12:37:49Z | |
dc.date.issued | 2020-01-01 | |
dc.description.abstract | Objectives: To determine CLLU1 gene levels and the relationship of that gene among other prognostic parameters in patients with chronic lymphocytic leukemia. Methods: Bone-marrow infiltration pattern, beta 2-microglobulin (beta(2)-M), cluster of differentiation (CD)38, and ZAP-70 status were recorded. CLLU1 levels were assessed by real-time polymerase chain reaction (RT-PCR) and expressed as folds. The relationship between CLLU1 and other known prognostic parameters was evaluated. Results: CLLU1 expression was positive in 81 patients and negative in 3 patients. The median (interquartile range {[}IQR]) CLLU1 level was 6.45 folds (3.75-16.57 folds) in patients with beta(2)-M normal values and 16.22 folds (3.91-62.00 folds) in patients with increased beta(2)-M (P = .15). Patients with a higher CD38 value than the median level had 3 times higher CLLU1 levels than the other group (P = .07). The median (IQR) CLLU1 level was 4.25 folds (2.75-13.71 folds) in patients with CLL who tested negative on ZAP-70, whereas it was 49.52 folds (15.06-446.36 folds) in those who tested positive via ZAP-70 (P = .005). Conclusions: CLLU1 is a specific parameter to CLL, and its level corresponds well with the ZAP-70 level. | |
dc.description.issue | 3 | |
dc.description.issue | MAY | |
dc.description.pages | 259-264 | |
dc.description.volume | 51 | |
dc.identifier.doi | 10.1093/labmed/lmz058 | |
dc.identifier.uri | https://hdl.handle.net/11443/2299 | |
dc.identifier.uri | http://dx.doi.org/10.1093/labmed/lmz058 | |
dc.identifier.wos | WOS:000580631000008 | |
dc.publisher | OXFORD UNIV PRESS | |
dc.relation.ispartof | LABORATORY MEDICINE | |
dc.subject | chronic lymphocytic leukemia | |
dc.subject | chronic lymphocytic leukemia upregulated 1 gene | |
dc.subject | CLLU1 | |
dc.subject | ZAP-70 | |
dc.subject | prognosis | |
dc.subject | beta(2)-microglobulin | |
dc.title | The Impact and Prognostic Significance of Chronic Lymphocytic Leukemia Upregulated 1 (CLLU1) Gene Expression in Patients with Chronic Lymphocytic Leukemia: A Single Center Experience | |
dc.type | Article |