Protective effect of pomegranate juice on retinal oxidative stress in streptozotocin-induced diabetic rats

dc.contributor.authorTugcu, Betul
dc.contributor.authorNacaroglu, Senay Asik
dc.contributor.authorGedikbasi, Asuman
dc.contributor.authorUhri, Mehmet
dc.contributor.authorAcar, Nur
dc.contributor.authorOzdemir, Hakan
dc.date.accessioned2023-02-21T12:38:12Z
dc.date.available2023-02-21T12:38:12Z
dc.date.issued2017-01-01
dc.description.abstractAIM: To investigate the effect of pomegranate juice (PJ) intake on overall oxidation status in retinas of diabetic rats. METHODS: Twenty-seven rats were divided into four groups as control (CO), diabetic (DM), control treated with PJ (CO-PJ), and diabetic treated with PJ (DM-PJ). The retina tissues were used to determine 8-hydroxy2 `-deoxyguanosine (8OHdG), malondialdehyde (MDA), reduced glutathione (GSH) levels, and the enzyme activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). RESULTS: The levels of 8OHdG and MDA were significantly increased in the retina of DM group compared to CO group (P= 0.001, P< 0.001 respectively). Both 8OHdG and MDA levels were decreased in PJ-DM group compared to DM group (P= 0.004, P< 0.001 respectively). The activities of antioxidant enzymes GSH, SOD, and GDH-Px were significantly decreased in the retina of DM group compared to CO group (P= 0.01). GSH and GSH-Px activities were higher in PJ-DM group compared with DM group (P= 0.010, P= 0.042, respectively) but SOD activity was not statistically different (P= 0.938). CONCLUSION: PJ intake is found to be effective in decreasing oxidative end products, and in increasing the activities of antioxidant enzymes in diabetic retinas of rats, which suggests it may be effective against oxidative stress in diabetic retinas.
dc.description.issue11
dc.description.issueNOV 18
dc.description.pages1662-1668
dc.description.volume10
dc.identifier.doi10.18240/ijo.2017.11.05
dc.identifier.urihttps://hdl.handle.net/11443/2351
dc.identifier.urihttp://dx.doi.org/10.18240/ijo.2017.11.05
dc.identifier.wosWOS:000415603300005
dc.publisherIJO PRESS
dc.relation.ispartofINTERNATIONAL JOURNAL OF OPHTHALMOLOGY
dc.subjectantioxidant enzymes
dc.subjectdiabetic retinopathy
dc.subjectimmunohistochemical staining
dc.subjectoxidative stress
dc.subjectpomegranate juice
dc.titleProtective effect of pomegranate juice on retinal oxidative stress in streptozotocin-induced diabetic rats
dc.typeArticle

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