Epithelial-to-Mesenchymal Transition Is Not a Major Modulating Factor in the Cytotoxic Response to Natural Products in Cancer Cell Lines

dc.contributor.authorKucukkaraduman, Baris
dc.contributor.authorCicek, Ekin Gokce
dc.contributor.authorAkbar, Muhammad Waqas
dc.contributor.authorCanli, Secil Demirkol
dc.contributor.authorVural, Burcak
dc.contributor.authorGure, Ali Osmay
dc.date.accessioned2023-02-21T12:36:48Z
dc.date.available2023-02-21T12:36:48Z
dc.date.issued2021-01-01
dc.description.abstractNumerous natural products exhibit antiproliferative activity against cancer cells by modulating various biological pathways. In this study, we investigated the potential use of eight natural compounds (apigenin, curcumin, epigallocatechin gallate, fisetin, forskolin, procyanidin B2, resveratrol, urolithin A) and two repurposed agents (fulvestrant and metformin) as chemotherapy enhancers and mesenchymal-to-epithelial (MET) inducers of cancer cells. Screening of these compounds in various colon, breast, and pancreatic cancer cell lines revealed anti-cancer activity for all compounds, with curcumin being the most effective among these in all cell lines. Although some of the natural products were able to induce MET in some cancer cell lines, the MET induction was not related to increased synergy with either 5-FU, irinotecan, gemcitabine, or gefitinib. When synergy was observed, for example with curcumin and irinotecan, this was unrelated to MET induction, as assessed by changes in E-cadherin and vimentin expression. Our results show that MET induction is compound and cell line specific, and that MET is not necessarily related to enhanced chemosensitivity.
dc.description.issue19
dc.description.issueOCT
dc.description.volume26
dc.identifier.doi10.3390/molecules26195858
dc.identifier.urihttps://hdl.handle.net/11443/2154
dc.identifier.urihttp://dx.doi.org/10.3390/molecules26195858
dc.identifier.wosWOS:000707765700001
dc.publisherMDPI
dc.relation.ispartofMOLECULES
dc.subjectnatural products
dc.subjectcancer
dc.subjectchemotherapy resistance
dc.subjectepithelial-to-mesenchymal transition
dc.subjectmesenchymal-to-epithelial transition
dc.titleEpithelial-to-Mesenchymal Transition Is Not a Major Modulating Factor in the Cytotoxic Response to Natural Products in Cancer Cell Lines
dc.typeArticle

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