An Expert Panel Statement on the Beneficial Effects of Human Milk Oligosaccharides (HMOs) in Early Life and Potential Utility of HMO-Supplemented Infant Formula in Cow's Milk Protein Allergy

Sadeleştirilmiş öğe sayfası
dc.contributor.authorSekerel, Bulent Enis
dc.contributor.authorBingol, Gulbin
dc.contributor.authorCokugras, Fugen Cullu
dc.contributor.authorCokugras, Haluk
dc.contributor.authorKansu, Aydan
dc.contributor.authorOzen, Hasan
dc.contributor.authorTamay, Zeynep
dc.date.accessioned2023-02-21T12:37:36Z
dc.date.available2023-02-21T12:37:36Z
dc.date.issued2021-01-01
dc.description.abstractThis review by pediatric gastroenterology and allergy-immunology experts aimed to address the biological roles of human milk oligosaccharides (HMOs) and the potential utility of HMOs in prevention of allergy with particular emphasis on cow's milk protein allergy (CMPA). The participating experts consider HMOs amongst the most critical bioactive components of human milk, which act as antimicrobials and antivirals by preventing pathogen adhesion to epithelial cells, as intestinal epithelial cell modulators by enhancing maturation of intestinal mucosa and intestinal epithelial barrier function, as prebiotics by promoting healthy microbiota composition and as immunomodulators by modulating immune cells indirectly and directly. Accordingly, the participating experts consider the proposed link between HMOs and prevention of allergy to be primarily based on the impact of HMO on gut microbiota, intestinal mucosal barrier, immunomodulation and immune maturation. Along with the lower risk of respiratory and gastrointestinal infections, HMO supplemented formulas seem to be promising alternatives in the management of CMPA. Nonetheless, the effects of individual as well as complex mixtures of HMO in terms of clear clinical and immunological effects and tolerance development need to be further explored to fully realize the immunomodulatory mechanisms and the potential for HMOs in prevention of allergic diseases and CMPA.
dc.description.pages1147-1164
dc.description.volume14
dc.identifier.doi10.2147/JAA.S323734
dc.identifier.urihttps://hdl.handle.net/11443/2267
dc.identifier.urihttp://dx.doi.org/10.2147/JAA.S323734
dc.identifier.wosWOS:000704083700001
dc.publisherDOVE MEDICAL PRESS LTD
dc.relation.ispartofJOURNAL OF ASTHMA AND ALLERGY
dc.subjecthuman milk oligosaccharides
dc.subjectgut microbiota
dc.subjectintestinal mucosal barrier
dc.subjectinfant formula
dc.subjectimmune tolerance
dc.subjectcow's milk protein allergy
dc.titleAn Expert Panel Statement on the Beneficial Effects of Human Milk Oligosaccharides (HMOs) in Early Life and Potential Utility of HMO-Supplemented Infant Formula in Cow's Milk Protein Allergy
dc.typeArticle
Dosyalar
Koleksiyonlar
WOS