Ovarian reserve assessment in crohn patients of reproductive age

dc.contributor.authorKadirogullari, Pinar
dc.contributor.authorBahat, Pinar Yalcin
dc.contributor.authorSelcuki, Fitnat Topbas
dc.contributor.authorIrak, Kader
dc.contributor.authorSeckin, Kerem Doga
dc.date.accessioned2023-02-21T12:34:22Z
dc.date.available2023-02-21T12:34:22Z
dc.date.issued2021-01-01
dc.description.abstractObjectives: Crohn's disease (CD) is a repeating bowel disease characterized by remission and exacerbation periods. The disease mostly affects adults of reproductive age. Women with desires to conceive are concerned about the effects of CD on their fertility. To demonstrate the relationship between ovarian reserve and CD anti-Mullerian hormone (AMH) levels, antral follicle count (AFC) and ovarian volume were evaluated. Material and methods: The prospective case-controlled study was conducted at a tertiary referral center in Istanbul between March-August 2019. Ovarian functions were evaluated in 50 patients with CD and in 95 healthy women. Serum gonadotropin and AMH levels were determined. AFCs and ovarian volumes were calculated for all subjects. Results: AMH levels were significantly lower in CD patients (2.1 +/- 0.8) compared to the control group (3.3 +/- 0.9) (P = 0.001). Serum AMH levels were significantly lower in patients with active CD (2.1 +/- 0.6) than the CD patients in remission (2.6 +/- 0.8) (p = 0.002). Ovarian volumes and AFC values were significantly lower in both ovaries in CD patients compared to the controls (p < 0.05). Conclusions: AMH levels, ovarian volume and AFC counts, and thus ovarian reserve was shown to be decreased in CD patients of reproductive age compared to healthy control subjects. Because possible effects of inflammatory damage may be seen in newly diagnosed female CD patients who desire to have a child, we believe that CD patients should be comprehensively assessed for ovarian reserve.
dc.description.issue8
dc.description.pages550-555
dc.description.volume92
dc.identifier.doi10.5603/GP.a2020.0170
dc.identifier.urihttps://hdl.handle.net/11443/1729
dc.identifier.urihttp://dx.doi.org/10.5603/GP.a2020.0170
dc.identifier.wosWOS:000697370500003
dc.publisherVIA MEDICA
dc.relation.ispartofGINEKOLOGIA POLSKA
dc.subjectanti-mullerian hormone
dc.subjectcrohn disease
dc.subjectinflammatory bowel disease
dc.subjectovarian reserve
dc.titleOvarian reserve assessment in crohn patients of reproductive age
dc.typeArticle

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