Association Between Serum Pregnancy-Associated Plasma Protein-A and Bicarbonate in Hemodialysis Patients
dc.contributor.author | Bicik, Zerrin | |
dc.contributor.author | Coskun, Abdurrahman | |
dc.contributor.author | Serteser, Mustafa | |
dc.contributor.author | Bulur, Atilla | |
dc.contributor.author | Mese, Meral | |
dc.contributor.author | Unsal, Ibrahim | |
dc.date.accessioned | 2023-02-21T12:33:00Z | |
dc.date.available | 2023-02-21T12:33:00Z | |
dc.date.issued | 2014-01-01 | |
dc.description.abstract | Background Acidosis is associated with protein-energy malnutrition, inflammation, and bone disease, and low bicarbonate levels have been implicated in higher mortality rates in chronic kidney disease. Recently, the concentration of serum pregnancy-associated plasma protein-A (PAPP-A) has become accepted as a prognostic marker in hemodialysis patients. This study determined the relationship between PAPP-A and bicarbonate levels in these patients. Methods The study enrolled 65 hemodialysis patients (41 males, 24 females) and 26 control subjects (11 males, 15 females). Serum PAPP-A, intact parathormone (iPTH), calcium, phosphorus (P), and bicarbonate levels were measured. Correlations between PAPP-A and bicarbonate, iPTH, calcium, and phosphorus were evaluated. Results Median PAPP-A levels were significantly higher in hemodialysis patients {[}15.1 (<0.03-158.8) ng/ml] than in control subjects {[}6.6 (<0.03-16.4) ng/ml] (P < 0.05). There were statistically significant correlations between serum PAPP-A and bicarbonate, iPTH, and P in hemodialysis patients but not in control subjects. Conclusion Elevation of serum PAPP-A has been found in hemodialysis patients and its significant correlation with bicarbonate suggests that it may be a prognostic factor. | |
dc.description.issue | 2 | |
dc.description.issue | MAR | |
dc.description.pages | 114-117 | |
dc.description.volume | 28 | |
dc.identifier.doi | 10.1002/jcla.21653 | |
dc.identifier.uri | https://hdl.handle.net/11443/1351 | |
dc.identifier.uri | http://dx.doi.org/10.1002/jcla.21653 | |
dc.identifier.wos | WOS:000332840500006 | |
dc.publisher | JOHN WILEY \& SONS INC | |
dc.relation.ispartof | JOURNAL OF CLINICAL LABORATORY ANALYSIS | |
dc.subject | PAPP-A | |
dc.subject | acidosis | |
dc.subject | hemodialysis | |
dc.subject | acute coronary syndrome | |
dc.subject | bicarbonate | |
dc.title | Association Between Serum Pregnancy-Associated Plasma Protein-A and Bicarbonate in Hemodialysis Patients | |
dc.type | Article |