Association Between Serum Pregnancy-Associated Plasma Protein-A and Bicarbonate in Hemodialysis Patients

dc.contributor.authorBicik, Zerrin
dc.contributor.authorCoskun, Abdurrahman
dc.contributor.authorSerteser, Mustafa
dc.contributor.authorBulur, Atilla
dc.contributor.authorMese, Meral
dc.contributor.authorUnsal, Ibrahim
dc.date.accessioned2023-02-21T12:33:00Z
dc.date.available2023-02-21T12:33:00Z
dc.date.issued2014-01-01
dc.description.abstractBackground Acidosis is associated with protein-energy malnutrition, inflammation, and bone disease, and low bicarbonate levels have been implicated in higher mortality rates in chronic kidney disease. Recently, the concentration of serum pregnancy-associated plasma protein-A (PAPP-A) has become accepted as a prognostic marker in hemodialysis patients. This study determined the relationship between PAPP-A and bicarbonate levels in these patients. Methods The study enrolled 65 hemodialysis patients (41 males, 24 females) and 26 control subjects (11 males, 15 females). Serum PAPP-A, intact parathormone (iPTH), calcium, phosphorus (P), and bicarbonate levels were measured. Correlations between PAPP-A and bicarbonate, iPTH, calcium, and phosphorus were evaluated. Results Median PAPP-A levels were significantly higher in hemodialysis patients {[}15.1 (<0.03-158.8) ng/ml] than in control subjects {[}6.6 (<0.03-16.4) ng/ml] (P < 0.05). There were statistically significant correlations between serum PAPP-A and bicarbonate, iPTH, and P in hemodialysis patients but not in control subjects. Conclusion Elevation of serum PAPP-A has been found in hemodialysis patients and its significant correlation with bicarbonate suggests that it may be a prognostic factor.
dc.description.issue2
dc.description.issueMAR
dc.description.pages114-117
dc.description.volume28
dc.identifier.doi10.1002/jcla.21653
dc.identifier.urihttps://hdl.handle.net/11443/1351
dc.identifier.urihttp://dx.doi.org/10.1002/jcla.21653
dc.identifier.wosWOS:000332840500006
dc.publisherJOHN WILEY \& SONS INC
dc.relation.ispartofJOURNAL OF CLINICAL LABORATORY ANALYSIS
dc.subjectPAPP-A
dc.subjectacidosis
dc.subjecthemodialysis
dc.subjectacute coronary syndrome
dc.subjectbicarbonate
dc.titleAssociation Between Serum Pregnancy-Associated Plasma Protein-A and Bicarbonate in Hemodialysis Patients
dc.typeArticle

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