Zinc finger protein 384 (ZNF384) impact on childhood mixed phenotype acute leukemia and B-cell precursor acute lymphoblastic leukemia
dc.contributor.author | Sudutan, Tugce | |
dc.contributor.author | Erbilgin, Yucel | |
dc.contributor.author | Hatirnaz Ng, Ozden | |
dc.contributor.author | Karaman, Serap | |
dc.contributor.author | Karakas, Zeynep | |
dc.contributor.author | Kucukcankurt, Fulya | |
dc.contributor.author | Celkan, Tiraje | |
dc.contributor.author | Timur, Cetin | |
dc.contributor.author | Ozdemir, Gul Nihal | |
dc.contributor.author | Hacisalihoglu, Sadan | |
dc.contributor.author | Gelen, Sema Aylan | |
dc.contributor.author | Sayitoglu, Muge | |
dc.date.accessioned | 2023-02-21T12:39:28Z | |
dc.date.available | 2023-02-21T12:39:28Z | |
dc.date.issued | 2022-01-01 | |
dc.description.abstract | B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a heterogeneous malignancy and consists of several genetic abnormalities. Some of these abnormalities are used in clinics for risk calculation and treatment decisions. Patients with ZNF384 rearrangements had a distinct expression profile regardless of their diagnosis, BCP-ALL or mixed phenotype acute leukemia (MPAL) and defined as a new subtype of ALL. In this study, we screened 42 MPAL and 91 BCP-ALL patients for the most common ZNF384 fusions | |
dc.description.abstract | ZNF384::TCF3, ZNF384::EP300 and ZNF384::TAF15 by using PCR. We identified ZNF384 fusions in 9.5\% of MPAL and 7.6\% of BCP-ALL. A novel breakpoint was identified in ZNF384::TCF3 fusion in one BCP-ALL patient. T-myeloid MPAL patients showed significantly lower ZNF384 expression compared to lymphoid groups. Patients with ZNF384r had intermediate survival rates based on other subtypes. Prognostic and patient-specific treatment evaluation of ZNF384 fusions in both ALL and MPAL might help to improve risk characterization of patients. | |
dc.description.issue | 12 | |
dc.description.issue | OCT 15 | |
dc.description.pages | 2931-2939 | |
dc.description.volume | 63 | |
dc.identifier.doi | 10.1080/10428194.2022.2095630 | |
dc.identifier.uri | https://hdl.handle.net/11443/2511 | |
dc.identifier.uri | http://dx.doi.org/10.1080/10428194.2022.2095630 | |
dc.identifier.wos | WOS:000835775800001 | |
dc.publisher | TAYLOR \& FRANCIS LTD | |
dc.relation.ispartof | LEUKEMIA \& LYMPHOMA | |
dc.subject | B-cell precursor ALL | |
dc.subject | mixed phenotype acute leukemia | |
dc.subject | ZNF384 fusion | |
dc.subject | ZNF384 expression levels | |
dc.title | Zinc finger protein 384 (ZNF384) impact on childhood mixed phenotype acute leukemia and B-cell precursor acute lymphoblastic leukemia | |
dc.type | Article |