Comparison of warm fluid and cold fluid resuscitation during uncontrolled hemorrhagic shock model in rats

dc.contributor.authorDilmen, Serkan
dc.contributor.authorEryilmaz, Mehmet
dc.contributor.authorBalkan, Salih Mujdat
dc.contributor.authorSerdar, Muhittin
dc.contributor.authorDurusu, Murat
dc.contributor.authorYildirim, Ali Osman
dc.contributor.authorDilmen, Sanem Aslihan
dc.date.accessioned2023-02-21T12:38:47Z
dc.date.available2023-02-21T12:38:47Z
dc.date.issued2017-01-01
dc.description.abstractBACKGROUND: This study was designed to compare the effects of resuscitation with cold and warm fluid on survival time, rate and volume of hemorrhage, hemodynamics, hypothermia, coagulopathy, acid-base balance, hematocrit, lactate, and base deficit during uncontrolled hemorrhagic shock (HS) model in rats. METHODS: HS model was created with splenic vascular and parenchymal injury in 29 rats under ketamine and xylazine anesthesia. Thirty minutes after the hemorrhage, the rats were randomized to receive 14.5 mL/kg 0.9\% sodium chloride solution at either 24 degrees C (Group I
dc.description.abstractn=9) or 4 degrees C (Group 2
dc.description.abstractn= 10) for 20 minutes. Groups I and 2 were compared with group that did not receive fluid (Group 3
dc.description.abstractn=10). Statistical data were represented as mean +/- SD. SPSS for Windows, Version 15.0 (SPSS, Inc., Chicago, IL, USA) software, Bonferroni-adjusted Mann-Whitney U test and Kaplan-Meier procedure were used to perform statistical data analysis. P value of <= 50.05 was considered statistically significant. RESULTS: Cold fluid resuscitation decreased survival time due to increased rate and volume of hemorrhage, acidosis, hypothermia, lactate, and base deficit and decreased blood pressure and hematocrit. CONCLUSION: There is a great need for further experimental and clinical trials on fluid resuscitation in trauma in order to define which fluid should be administered, temperature of the fluid, quantity to be delivered, and duration.
dc.description.issue4
dc.description.issueJUL
dc.description.pages287-293
dc.description.volume23
dc.identifier.doi10.5505/tjtes.2016.50487
dc.identifier.urihttps://hdl.handle.net/11443/2428
dc.identifier.urihttp://dx.doi.org/10.5505/tjtes.2016.50487
dc.identifier.wosWOS:000407527600003
dc.publisherTURKISH ASSOC TRAUMA EMERGENCY SURGERY
dc.relation.ispartofULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA \& EMERGENCY SURGERY
dc.subjectFluid resuscitation
dc.subjecthemorrhagic shock
dc.subjectintravenous cold fluid
dc.subjectrat
dc.titleComparison of warm fluid and cold fluid resuscitation during uncontrolled hemorrhagic shock model in rats
dc.typeArticle

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