Assessment of clinical outcomes in renal transplant recipients with COVID-19
dc.contributor.author | Yilmaz, Gulay | |
dc.contributor.author | Ebru, Ozdemir | |
dc.contributor.author | Ibrahim, Berber | |
dc.contributor.author | Ulkem, Cakir | |
dc.date.accessioned | 2023-02-21T12:32:33Z | |
dc.date.available | 2023-02-21T12:32:33Z | |
dc.date.issued | 2021-01-01 | |
dc.description.abstract | The coronavirus disease 2019 (COVID-19) has affected more than a hundred million individuals and caused more than three million deaths worldwide. Specific risk groups were defined for increased risk of mortality and morbidity in COVID-19, and renal transplant recipients are at a significantly increased risk regarding outcomes due to their immunosuppressed conditions. This study evaluated the general characteristics of kidney transplant recipients with COVID-19 infection. Among 1257 transplant cases, 56 had COVID-19 infection, and 23 (41\%) were hospitalized during the 9-month study period. Among all COVID-19 cases, 58\% were male with a mean age of 45.5 (+/- 13.2, 19-71) years, and the most frequent comorbidities were hypertension (70.9\%) and diabetes (23.6\%). Hospitalized patients were older (p = 0.03) and had higher rates of hypertension (p = 0.008), diabetes (p = 0.002), and ischemic heart disease (p = 0.03). Therapeutic management included antimetabolite withdrawal and prednisolone increase in 71\%, calcineurin inhibitor withdrawal in 8\% and decrease in 58\%, hydroxychloroquine in 17\%, tocilizumab in 3\%, and antivirals in 67\% of patients. Acute kidney injury and respiratory failure developed in 34\% and 85\%, respectively. The mortality rate was 23\%. These results emphasized that the COVID-19 infection in renal transplant recipients significantly increases the risk of morbidity and mortality. Therefore, these patients should be intervened earlier and monitored closely to prevent poor outcomes. | |
dc.description.issue | 12 | |
dc.description.issue | DEC | |
dc.description.pages | 6760-6764 | |
dc.description.volume | 93 | |
dc.identifier.doi | 10.1002/jmv.27271 | |
dc.identifier.uri | https://hdl.handle.net/11443/1145 | |
dc.identifier.uri | http://dx.doi.org/10.1002/jmv.27271 | |
dc.identifier.wos | WOS:000687317200001 | |
dc.publisher | WILEY | |
dc.relation.ispartof | JOURNAL OF MEDICAL VIROLOGY | |
dc.subject | COVID-19 | |
dc.subject | mortality | |
dc.subject | patient outcomes | |
dc.subject | renal transplant | |
dc.subject | transplant recipients | |
dc.title | Assessment of clinical outcomes in renal transplant recipients with COVID-19 | |
dc.type | Article |
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