Trans-Arterial Chemoembolization with 50 mu m Degradable Starch Microspheres Versus 300-500 mu m Drug Eluting Beads in Hepatocellular Carcinoma: A Comparative Analysis of Initial Treatment Outcomes

dc.contributor.authorYildiz, Isil
dc.contributor.authorDeniz, Sinan
dc.contributor.authorOzer, Ali
dc.contributor.authorCaliskan, Kosti
dc.date.accessioned2023-02-21T12:32:47Z
dc.date.available2023-02-21T12:32:47Z
dc.date.issued2022-01-01
dc.description.abstractBackground and Aims: Trans-arterial chemoembolization (TACE) has become a widely accepted treatment in unresectable hepatocellular carcinoma (HCC). We aimed at comparing the efficacy of Degradable Starch Microspheres (DSMs)-TACE with 50 +/- 7 mu m versus 300-500 mu m Drug Eluting Beads (DEB)-TACE in terms of initial clinical and radiological treatment response parameters. Material and Methods: A total of 54 patients with unresectable HCC who underwent DEB-TACE (n = 25) or DSMs-TACE (n = 29) were included in this retrospective study. Baseline demographic and clinical characteristics, duration of follow-up, local recurrence and survival status, as well as treatment outcome including treatment response via modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria, viable and total tumor diameter and serum alpha-fetoprotein (AFP) levels were analyzed in both study groups. Results: No significant difference was noted between the two groups in terms of local recurrence (31.6 vs. 16.7\%) or mortality (73.9 vs. 85.7\%) rates after 36-month and 12-month follow-up, respectively. DSMs-TACE vs. DEB-TACE was associated with significantly higher complete response rate (27.6 vs. 0.0\%, p = 0.011) and significant decrease in serum AFP levels (p = 0.013). Conclusion: Both DSMs-TACE with 50 +/- 7 mu m microspheres and 300-500 mu m DEB-TACE are effective for local control of unresectable HCC. Our findings revealed superiority of DSMs-TACE over DEB-TACEnin terms of initial clinical and radiological tumor response
dc.description.abstractthough no significant difference was noted between the two patient groups in terms of local recurrence or mortality during follow up.
dc.description.issue1
dc.description.volume106
dc.identifier.doi10.5334/jbsr.2594
dc.identifier.urihttps://hdl.handle.net/11443/1266
dc.identifier.urihttp://dx.doi.org/10.5334/jbsr.2594
dc.identifier.wosWOS:000769152100009
dc.publisherUBIQUITY PRESS LTD
dc.relation.ispartofJOURNAL OF THE BELGIAN SOCIETY OF RADIOLOGY
dc.subjecthepatocelluler carsinoma
dc.subjecttrans-arterial chemoembolization
dc.subjectdegradable starch microspheres
dc.subjectdrug eluting beads
dc.subjecttreatment outcome
dc.titleTrans-Arterial Chemoembolization with 50 mu m Degradable Starch Microspheres Versus 300-500 mu m Drug Eluting Beads in Hepatocellular Carcinoma: A Comparative Analysis of Initial Treatment Outcomes
dc.typeArticle

Files

Collections