Optimal cytoreduction, depth of myometrial invasion, and age are independent prognostic factors for survival in women with uterine papillary serous and clear cell carcinomas
Optimal cytoreduction, depth of myometrial invasion, and age are independent prognostic factors for survival in women with uterine papillary serous and clear cell carcinomas
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Tarih
2016-01-01
Yazarlar
Solmaz, Ulas
Mat, Emre
Ekin, Atalay
Gezer, Cenk
Biler, Alper
Peker, Nuri
Ayaz, Duygu
Sanci, Muzaffer
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
Yayınevi
ELSEVIER SCIENCE BV
Dergi Adı
INTERNATIONAL JOURNAL OF SURGERY
Özet
Objective: The purpose of this study was to investigate the clinicopathological characteristics, treatment methods, and prognostic factors in women with uterine papillary serous carcinoma (UPSC) and uterine clear-cell carcinoma (UCCC). Study design: All patients who had undergone surgery for UPCS and UCCC between January 1995 and December 2012 were retrospectively reviewed. Patients with missing data, who did not undergo surgical staging and patients with mixed tumor histology were excluded. Multivariate regression models were used to identify the risk factors for overall survival (OS) and progression-free survival (PFS). Results: A total of 49 UPSC and 22 UCCC women were included. The majority of the patients were at stage I {[}IA, 22 (31\%) and IB, 18 (25.4\%)]. Stages II, III, and IV were identified in 9 (12.7\%), 13 (18.3\%), and 9 (12.7\%) of cases, respectively. Optimal cytoreduction was achieved in 71.8\% of cases. Recurrences occurred in 16 patients (22.5\%). The 5-year OS rates were 67\% for UPSC
76\% for UCCC
68\% for both histology, respectively. Multivariate analysis pointed out that age > 67 years (odds ratio (OR): 3.85, p = 0.009 and OR: 3.35, p = 0.014), > 50\% myometrial invasion (MI) (OR: 2.87, p = 0.037 and OR: 2.46, p = 0.046) and optimal cytoreduction (OR: 3.26, p = 0.006 and OR: 2.77, p = 0.015) were the independent prognostic factors for both PFS and OS. Conclusions: Our study demonstrated that optimal cytoreduction, > 50\% MI, and age > 67 years are the most significant factors affecting survival in women with UPSC and UCCC. (C) 2016 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.
76\% for UCCC
68\% for both histology, respectively. Multivariate analysis pointed out that age > 67 years (odds ratio (OR): 3.85, p = 0.009 and OR: 3.35, p = 0.014), > 50\% myometrial invasion (MI) (OR: 2.87, p = 0.037 and OR: 2.46, p = 0.046) and optimal cytoreduction (OR: 3.26, p = 0.006 and OR: 2.77, p = 0.015) were the independent prognostic factors for both PFS and OS. Conclusions: Our study demonstrated that optimal cytoreduction, > 50\% MI, and age > 67 years are the most significant factors affecting survival in women with UPSC and UCCC. (C) 2016 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.
Açıklama
Anahtar kelimeler
Age, Myometrial invasion, Optimal cytoreduction, Uterine clear-cell carcinoma, Uterine papillary serous carcinoma