Investigation of the relationship between cord clamping time and risk of hyperbilirubinemia
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Date
2020-01-01
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Publisher
TURKISH J PEDIATRICS
Abstract
Background. Although the relationship between umbilical cord clamping time and various parameters such as hemoglobin (Hb) levels, iron deficiency, and risk of neonatal jaundice has previously been studied, to the best of our knowleadge there have been no studies investigating the relationship between cord clamping time and the risk of significant hyperbilirubinemia. We aimed to investigate the relationship between the time of umbilical cord clamping and transcutaneous bilirubin (TcB) measurements made on various postnatal hours, Hb and serum total bilirubin (STB) levels measured on postnatal 4th day, and the risk of development of significant hyperbilirubinemia requiring phototherapy treatment. Methods. Eligible newborns were divided into two groups on the basis of the time of cord clamping: those clamped late (60 seconds or more
Group I) and those clamped early (less than 60 seconds
Group II). Groups were compared with respect to the parameters of cord Hb, postnatal TcB measurements at 6th, 48th, 96th and 168th hours, and 96th hour Hb, STB and direct bilirubin levels. Results. TcB levels at the 96th and 168th hour were significantly higher in Group I when compared to Group II (p<0.001 and p<0.001, respectively). The 96th hour STB level was significantly higher in Group I when compared to Group II (p<0.001). The need of phototherapy requirement was higher in Group I when compared to Group II (p{*}3.001). Increase in cord blood Hb for each 1 gr/dl caused a 3.94-fold increased risk in the requirement of phototherapy treatment. Cord clamping time showed statistically significant positive correlations with both cord blood and 96th hour venous Hb levels, with both 96th hour and 168th hour TcB levels, and with 96th hour STB levels. Conclusions. Newborns whose cords are clamped late should be followed up closely with respect to high postnatal bilirubin levels and other risks associated with significant hyperbilirubinemia requiring phototherapy treatment.
Group I) and those clamped early (less than 60 seconds
Group II). Groups were compared with respect to the parameters of cord Hb, postnatal TcB measurements at 6th, 48th, 96th and 168th hours, and 96th hour Hb, STB and direct bilirubin levels. Results. TcB levels at the 96th and 168th hour were significantly higher in Group I when compared to Group II (p<0.001 and p<0.001, respectively). The 96th hour STB level was significantly higher in Group I when compared to Group II (p<0.001). The need of phototherapy requirement was higher in Group I when compared to Group II (p{*}3.001). Increase in cord blood Hb for each 1 gr/dl caused a 3.94-fold increased risk in the requirement of phototherapy treatment. Cord clamping time showed statistically significant positive correlations with both cord blood and 96th hour venous Hb levels, with both 96th hour and 168th hour TcB levels, and with 96th hour STB levels. Conclusions. Newborns whose cords are clamped late should be followed up closely with respect to high postnatal bilirubin levels and other risks associated with significant hyperbilirubinemia requiring phototherapy treatment.
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Keywords
hyperbilirubinemia, risk management, transcutaneous bilirubin measurements