The European Biological Variation Study (EuBIVAS): Biological Variation Data for Coagulation Markers Estimated by a Bayesian Model

dc.contributor.authorAarsand, Aasne K.
dc.contributor.authorKristoffersen, Ann Helen
dc.contributor.authorSandberg, Sverre
dc.contributor.authorStove, Bard
dc.contributor.authorCoskun, Abdurrahman
dc.contributor.authorFernandez-Calle, Pilar
dc.contributor.authorDiaz-Garzon, Jorge
dc.contributor.authorGuerra, Elena
dc.contributor.authorCeriotti, Ferruccio
dc.contributor.authorJonker, Niels
dc.contributor.authorRoraas, Thomas
dc.contributor.authorCarobene, Anna
dc.contributor.authorChem, European Federation Clinical
dc.date.accessioned2023-02-21T12:40:29Z
dc.date.available2023-02-21T12:40:29Z
dc.date.issued2021-01-01
dc.description.abstractBACKGROUND: For biological variation (BV) data to be safely used, data must be reliable and relevant to the population in which they are applied. We used samples from the European Biological Variation Study (EuBIVAS) to determine BV of coagulation markers by a Bayesian model robust to extreme observations and used the derived within-participant BV estimates {[}CVP(i)] to assess the applicability of the BV estimates in clinical practice. METHOD: Plasma samples were drawn from 92 healthy individuals for 10 consecutive weeks at 6 European laboratories and analyzed in duplicate for activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen, D-dimer, antithrombin (AT), protein C, protein S free, and factor VIII (FVIII). A Bayesian model with Student t likelihoods for samples and replicates was applied to derive CVP(i) and predicted BV estimates with 95\% credibility intervals. RESULTS: For all markers except D-dimer, CVP( i) were homogeneously distributed in the overall study population or in subgroups. Mean within-subject estimates (CVI) were <5\% for APTT, PT, AT, and protein S free, <10\% for protein C and FVIII, and <12\% for fibrinogen. For APTT, protein C, and protein S free, estimates were significantly lower in men than in women <= 50 years. CONCLUSION: For most coagulation markers, a common CVI estimate for men and women is applicable, whereas for APTT, protein C, and protein S free, sex-specific reference change values should be applied. The use of a Bayesian model to deliver individual CVP(i) allows for improved interpretation and application of the data.
dc.description.issue9
dc.description.issueSEP
dc.description.pages1259-1270
dc.description.volume67
dc.identifier.doi10.1093/clinchem/hvab100
dc.identifier.urihttps://hdl.handle.net/11443/2622
dc.identifier.urihttp://dx.doi.org/10.1093/clinchem/hvab100
dc.identifier.wosWOS:000696254400014
dc.publisherOXFORD UNIV PRESS INC
dc.relation.ispartofCLINICAL CHEMISTRY
dc.subjectbiological variation
dc.subjectwithin-subject biological variation
dc.subjectanalytical performance specification
dc.subjectBayesian model
dc.subjectreference change value
dc.titleThe European Biological Variation Study (EuBIVAS): Biological Variation Data for Coagulation Markers Estimated by a Bayesian Model
dc.typeArticle

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