Is it Possible to Diagnose Endometrium Cancer with the Levels of Prolactin, Eotaxin, E-selectin and Ca 125?

Abstract

Objective: The aim of this study to evaluate possible serum markers for distinction of endometrial carcinoma (EC) from benign uterine gynecologic diseases. Methods: The study group consisted of 65 patients who were diagnosed with histologically confirmed EC were compared with 65 women who had operation indication for benign uterine diseases with fasting blood serum levels which were taken prior to surgery in terms of prolactin, eotaxin, e-selectin and Ca 125 concentrations. Results: Serum prolactin (20.7 +/- 18 and 16.2 +/- 13), eotaxin (219.4 +/- 95 and 205.15 +/- 80) and e-selectin (67.2 +/- 29 and 61.5 +/- 29) levels were not significantly different between EC and the other group (p>0.05). Ca 125 levels (36.6 +/- 40 and 18.8 +/- 9) were significantly higher in EC group when compared with the benign uterine patology group (p<0.05). Conclusion: Although serum levels of prolactin, eotaxin, e-selectin were higher in EC group, those were not statistically significant. Although, serum Ca 125 levels were siginificantly higher in EC group, diagnostic role of Ca 125 is limited. There is currently no marker to distinguish EC from benign uterine pathologies.