Cofilin-1 as a potential biomarker to evaluate acute kidney injury

dc.contributor.authorCoskun, Abdurrahman
dc.contributor.authorUcal, Yasemin
dc.contributor.authorBerber, Ibrahim
dc.contributor.authorCakir, Ulkem
dc.contributor.authorSerteser, Mustafa
dc.contributor.authorMoldur, Derya Emel
dc.contributor.authorDerelioglu, Ecenur Izzete
dc.contributor.authorYozgatli, Tahir Koray
dc.contributor.authorOzpinar, Aysel
dc.contributor.authorUnsal, Ibrahim
dc.date.accessioned2023-02-21T12:32:17Z
dc.date.available2023-02-21T12:32:17Z
dc.date.issued2019-01-01
dc.description.abstractAcute kidney injury (AKI) is a worldwide health problem and defined by rapid loss of excretory function of the kidney with the accumulation of metabolic end products. For effective treatment and prevent complications the early diagnosis of AKI is crucial. The current analytes used to diagnose AKI are not adequately sensitive and specific and therefore clinicians need new biomarkers. One of the new promising biomarker candidates of renal injury is cofilin-1. Previously, in our laboratory we isolated cofilin-1 in kidney preservation solution prior to transplantation and attempted to measure serum cofilin-1 in renal transplanted patients. However, cofilin-1 was not accurately measured in serum samples due to the methodological issues. In this mini-review, we summarized the current knowledge and concepts both in the literature and our experiences with cofilin-1 as a potential biomarker for the diagnosis and management of AKI.
dc.description.issue1
dc.description.issueFEB
dc.description.pages9-15
dc.description.volume44
dc.identifier.doi10.1515/tjb-2018-0287
dc.identifier.urihttps://hdl.handle.net/11443/955
dc.identifier.urihttp://dx.doi.org/10.1515/tjb-2018-0287
dc.identifier.wosWOS:000461427300002
dc.publisherWALTER DE GRUYTER GMBH
dc.relation.ispartofTURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
dc.subjectCofilin-1
dc.subjectBiomarker
dc.subjectAcute kidney injury
dc.subjectRenal transplantation
dc.subjectKidney preservation solution
dc.titleCofilin-1 as a potential biomarker to evaluate acute kidney injury
dc.typeArticle

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