Biological variation and reference change value data for serum copper, zinc and selenium in Turkish adult population

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dc.contributor.authorBal, Ceylan
dc.contributor.authorErdogan, Serpil
dc.contributor.authorGok, Gamze
dc.contributor.authorNural, Cemil
dc.contributor.authorOzbek, Betul
dc.contributor.authorErcan, Mujgan
dc.contributor.authorSerdar, Muhittin
dc.contributor.authorErel, Ozcan
dc.date.accessioned2023-02-21T12:37:48Z
dc.date.available2023-02-21T12:37:48Z
dc.date.issued2021-01-01
dc.description.abstractObjectives: Calculation of biological variation (BV) components is very important in evaluating whether a test result is clinically significant. The aim of this study is to analyze BV components for copper, zinc and selenium in a cohort of healthy Turkish participants. Methods: A total of 10 serum samples were collected from each of the 15 healthy individuals (nine female, six male), once a week, during 10 weeks. Copper, zinc and selenium levels were analyzed by atomic absorption spectrometer. BV parameters were calculated with the approach suggested by Fraser. Results: Analytical variation (CVA), within-subject BV (CVI), between-subject BV (CVG) values were 8.4, 7.1 and 4.3 for copper
dc.description.abstract4.2, 9.1 and 13.7 for zinc
dc.description.abstract7.6, 2.5 and 6.9 for selenium, respectively. Reference change values (RCV) were 30.46, 27.56 and 22.16\% for copper, zinc and selenium, respectively. The index of individuality (II) values were 1.65, 0.66 and 0.36 for copper, zinc and selenium, respectively. Conclusions: According to the results of this study, traditional reference intervals can be used for copper but we do not recommend using it for zinc and selenium. We think that it would be more accurate to use RCV value for zinc and selenium in terms of following significant changes in recurrent results of a patient.
dc.description.issue5
dc.description.issueOCT
dc.description.pages587-592
dc.description.volume46
dc.identifier.doi10.1515/tjb-2020-0298
dc.identifier.urihttps://hdl.handle.net/11443/2297
dc.identifier.urihttp://dx.doi.org/10.1515/tjb-2020-0298
dc.identifier.wosWOS:000712261700014
dc.publisherWALTER DE GRUYTER GMBH
dc.relation.ispartofTURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
dc.subjectbiological variation
dc.subjectcopper
dc.subjectreference change value
dc.subjectselenium
dc.subjectzinc
dc.titleBiological variation and reference change value data for serum copper, zinc and selenium in Turkish adult population
dc.typeArticle
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