Neuroprotective effects of erythropoietin against oxidant injury following brain irradiation: an experimental study

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dc.contributor.authorUgurluer, Gamze
dc.contributor.authorCebi, Aysegul
dc.contributor.authorMert, Handan
dc.contributor.authorMert, Nihat
dc.contributor.authorSerin, Meltem
dc.contributor.authorErkal, Haldun Sukru
dc.date.accessioned2023-02-21T12:37:44Z
dc.date.available2023-02-21T12:37:44Z
dc.date.issued2016-01-01
dc.description.abstractIntroduction: Radiation therapy (RT) is a major treatment modality, and the central nervous system is a dose-limiting organ in clinical RT. This experimental study aims to present the evaluation of the neuroprotective effects of erythropoietin (EPO) against oxidant injury following brain irradiation in rats. Material and methods: Forty Wistar rats were randomly assigned to four groups (n = 10 each). In group 1 the rats received no EPO and underwent sham RT. The rats in groups 2 and 3 received EPO. In group 2 rats underwent sham RT, while in group 3 rats received RT. The rats in group 4 received no EPO and underwent RT. Rats were irradiated using a Cobalt-60 teletherapy machine using a single fraction of 20 Gy covering the whole brain. Cervical dislocation euthanasia was performed. The nitrite and malondialdehyde (MDA) levels and the superoxide dismutase (SOD) and glutathione peroxidase (GSHPX) activities were evaluated in dissected brain tissues. Results: The nitrite and MDA levels were higher in the RT group (2.10 +/-0.62 ppm, 26.02 +/-2.16 nmol/ml
dc.description.abstractp < 0.05) and lower in the EPO + RT group (1.45 +/-0.12 ppm, 25.49 +/-1.90 nmol/ml
dc.description.abstractp < 0.05). The SOD and GSHPX activity was higher in the EPO + RT group (2.62 +/-0.49 U/mg, 1.75 +/-0.25 U/mg, p < 0.05). Conclusions: This study supports the probable neuroprotective effects of EPO against oxidant injury following brain irradiation in a rat model, presumably through decreasing free radical production and increasing expression of antioxidant enzymes.
dc.description.issue6
dc.description.issueDEC
dc.description.pages1348-1353
dc.description.volume12
dc.identifier.doi10.5114/aoms.2016.58622
dc.identifier.urihttps://hdl.handle.net/11443/2288
dc.identifier.urihttp://dx.doi.org/10.5114/aoms.2016.58622
dc.identifier.wosWOS:000386539200023
dc.publisherTERMEDIA PUBLISHING HOUSE LTD
dc.relation.ispartofARCHIVES OF MEDICAL SCIENCE
dc.subjectbrain
dc.subjectirradiation
dc.subjectoxidant injury
dc.subjectneuroprotective effects
dc.subjecterythropoietin
dc.titleNeuroprotective effects of erythropoietin against oxidant injury following brain irradiation: an experimental study
dc.typeArticle
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