Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA)

dc.contributor.authorSardanelli, Francesco
dc.contributor.authorTrimboli, Rubina M.
dc.contributor.authorHoussami, Nehmat
dc.contributor.authorGilbert, Fiona J.
dc.contributor.authorHelbich, Thomas H.
dc.contributor.authorAlvarez Benito, Marina
dc.contributor.authorBalleyguier, Corinne
dc.contributor.authorBazzocchi, Massimo
dc.contributor.authorBult, Peter
dc.contributor.authorCalabrese, Massimo
dc.contributor.authorCamps Herrero, Julia
dc.contributor.authorCartia, Francesco
dc.contributor.authorCassano, Enrico
dc.contributor.authorClauser, Paola
dc.contributor.authorCozzi, Andrea
dc.contributor.authorde Andrade, Danubia A.
dc.contributor.authorde Lima Docema, Marcos F.
dc.contributor.authorDepretto, Catherine
dc.contributor.authorDominelli, Valeria
dc.contributor.authorForrai, Gabor
dc.contributor.authorGirometti, Rossano
dc.contributor.authorHarms, Steven E.
dc.contributor.authorHilborne, Sarah
dc.contributor.authorIenzi, Raffaele
dc.contributor.authorLobbes I, Marc B.
dc.contributor.authorLosio, Claudio
dc.contributor.authorMann, Ritse M.
dc.contributor.authorMontemezzi, Stefania
dc.contributor.authorObdeijn, Inge-Marie
dc.contributor.authorOzcan, Umit A.
dc.contributor.authorPediconi, Federica
dc.contributor.authorPinker, Katja
dc.contributor.authorPreibsch, Heike
dc.contributor.authorRaya Povedano, Jose L.
dc.contributor.authorSacchetto, Daniela
dc.contributor.authorScaperrotta, Gianfranco P.
dc.contributor.authorSchiaffino, Simone
dc.contributor.authorSchlooz, Margrethe
dc.contributor.authorSzabo, Botond K.
dc.contributor.authorTaylor, Donna B.
dc.contributor.authorUlus, Ozden S.
dc.contributor.authorVan Goethem, Mireille
dc.contributor.authorVeltman, Jeroen
dc.contributor.authorWeigel, Stefanie
dc.contributor.authorWenkel, Evelyn
dc.contributor.authorZuiani, Chiara
dc.contributor.authorDi Leo, Giovanni
dc.date.accessioned2023-02-21T12:42:52Z
dc.date.available2023-02-21T12:42:52Z
dc.date.issued2022-01-01
dc.description.abstractObjectives Preoperative breast magnetic resonance imaging (MRI) can inform surgical planning but might cause overtreatment by increasing the mastectomy rate. The Multicenter International Prospective Analysis (MIPA) study investigated this controversial issue. Methods This observational study enrolled women aged 18-80 years with biopsy-proven breast cancer, who underwent MRI in addition to conventional imaging (mammography and/or breast ultrasonography) or conventional imaging alone before surgery as routine practice at 27 centers. Exclusion criteria included planned neoadjuvant therapy, pregnancy, personal history of any cancer, and distant metastases. Results Of 5896 analyzed patients, 2763 (46.9\%) had conventional imaging only (noMRI group), and 3133 (53.1\%) underwent MRI that was performed for diagnosis, screening, or unknown purposes in 692/3133 women (22.1\%), with preoperative intent in 2441/3133 women (77.9\%, MRI group). Patients in the MRI group were younger, had denser breasts, more cancers >= 20 mm, and a higher rate of invasive lobular histology than patients who underwent conventional imaging alone (p < 0.001 for all comparisons). Mastectomy was planned based on conventional imaging in 22.4\% (MRI group) versus 14.4\% (noMRI group) (p < 0.001). The additional planned mastectomy rate in the MRI group was 11.3\%. The overall performed first- plus second-line mastectomy rate was 36.3\% (MRI group) versus 18.0\% (noMRI group) (p < 0.001). In women receiving conserving surgery, MRI group had a significantly lower reoperation rate (8.5\% versus 11.7\%, p < 0.001). Conclusions Clinicians requested breast MRI for women with a higher a priori probability of receiving mastectomy. MRI was associated with 11.3\% more mastectomies, and with 3.2\% fewer reoperations in the breast conservation subgroup.
dc.description.issue3
dc.description.issueMAR
dc.description.pages1611-1623
dc.description.volume32
dc.identifier.doi10.1007/s00330-021-08240-x
dc.identifier.urihttps://hdl.handle.net/11443/2855
dc.identifier.urihttp://dx.doi.org/10.1007/s00330-021-08240-x
dc.identifier.wosWOS:000706927400006
dc.publisherSPRINGER
dc.relation.ispartofEUROPEAN RADIOLOGY
dc.subjectBreast cancer
dc.subjectMagnetic resonance imaging
dc.subjectMastectomy
dc.subjectBreast-conserving surgery
dc.subjectReoperation
dc.titleMagnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA)
dc.typeArticle

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