Helicobacter pylori treatment in Turkey: Current status and rational treatment options
Helicobacter pylori treatment in Turkey: Current status and rational treatment options
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Tarih
2020-01-01
Yazarlar
Kaplan, Mustafa
Tanoglu, Alpaslan
Duzenli, Tolga
Tozun, Ayse Nurdan
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
Yayınevi
KARE PUBL
Dergi Adı
NORTHERN CLINICS OF ISTANBUL
Özet
According to the TURHEP study, the prevalence of Helicobacter pylori in Turkey is 82.5\%. After FDA approval in 1995, many countries have used standard triple therapy (proton pump inhibitor 40 mg b.i.d clarithromycin 500 mg b.i.d and amoxicillin 1 gr b.i.d) for Helicobacter pylori treatment. In the beginning, eradication rates were above 90\% in many countries
however, current studies have demonstrated a prominent decrease in successful treatment rates, even down to 60\%. This unfavorable reduction stimulated searches for new treatment protocols. Treatment protocols differ according to country, prevalence, cost-effectiveness, antibiotic resistance, CYP2C19 polymorphism and eradication rates. Thus, each country/region needs to revise its own therapeutic results and the efficacy of various eradication regimens in the treatment of Helicobacter pylori. This report aims to review the current status of Helicobacter pylori treatment in Turkey and to provide recommendations for rational therapeutic considerations for the eradication of the bacterium.
however, current studies have demonstrated a prominent decrease in successful treatment rates, even down to 60\%. This unfavorable reduction stimulated searches for new treatment protocols. Treatment protocols differ according to country, prevalence, cost-effectiveness, antibiotic resistance, CYP2C19 polymorphism and eradication rates. Thus, each country/region needs to revise its own therapeutic results and the efficacy of various eradication regimens in the treatment of Helicobacter pylori. This report aims to review the current status of Helicobacter pylori treatment in Turkey and to provide recommendations for rational therapeutic considerations for the eradication of the bacterium.
Açıklama
Anahtar kelimeler
Eradication, Helicobacter pylori, proton pump inhibitors, Turkey