Cluster Analysis Revealed Two Hidden Phenotypes of Cluster Headache

dc.contributor.authorDikmen, Pinar Yalinay
dc.contributor.authorAri, Cagla
dc.contributor.authorSahin, Erdi
dc.contributor.authorErtas, Mustafa
dc.contributor.authorDomac, Fusun Mayda
dc.contributor.authorAydinlar, Elif Ilgaz
dc.contributor.authorSahin, Aysenur
dc.contributor.authorOzge, Aynur
dc.contributor.authorOzguner, Hilal
dc.contributor.authorKaradas, Omer
dc.contributor.authorShafiyev, Javid
dc.contributor.authorVuralli, Doga
dc.contributor.authorAktan, Cile
dc.contributor.authorOguz-Akarsu, Emel
dc.contributor.authorKarli, Necdet
dc.contributor.authorZarifoglu, Mehmet
dc.contributor.authorBolay, Hayrunisa
dc.contributor.authorEkizoglu, Esme
dc.contributor.authorOrhan, Elif Kocasoy
dc.contributor.authorTasdelen, Bahar
dc.contributor.authorBaykan, Betul
dc.date.accessioned2023-02-21T12:40:22Z
dc.date.available2023-02-21T12:40:22Z
dc.date.issued2022-01-01
dc.description.abstractObjectiveTo investigate the possible subgroups of patients with Cluster Headache (CH) by using K-means cluster analysis. MethodsA total of 209 individuals (mean (SD) age: 39.8 (11.3) years), diagnosed with CH by headache experts, participated in this cross-sectional multi-center study. All patients completed a semi-structured survey either face to face, preferably, or through phone interviews with a physician. The survey was composed of questions that addressed sociodemographic characteristics as well as detailed clinical features and treatment experiences. ResultsCluster analysis revealed two subgroups. Cluster one patients (n = 81) had younger age at diagnosis (31.04 (9.68) vs. 35.05 (11.02) years
dc.description.abstractp = 0.009), a higher number of autonomic symptoms (3.28 (1.16) vs. 1.99(0.95)
dc.description.abstractp < 0.001), and showed a better response to triptans (50.00\% vs. 28.00
dc.description.abstractp < 0.001) during attacks, compared with the cluster two subgroup (n = 122). Cluster two patients had higher rates of current smoking (76.0 vs. 33.0\%
dc.description.abstractp=0.002), higher rates of smoking at diagnosis (78.0 vs. 32.0\%
dc.description.abstractp=0.006), higher rates of parental smoking/tobacco exposure during childhood (72.0 vs. 33.0\%
dc.description.abstractp = 0.010), longer duration of attacks with (44.21 (34.44) min. vs. 34.51 (24.97) min
dc.description.abstractp=0.005) and without (97.50 (63.58) min. vs. (83.95 (49.07) min
dc.description.abstractp = 0.035) treatment and higher rates of emergency department visits in the last year (81.0 vs. 26.0\%
dc.description.abstractp< 0.001). ConclusionsCluster one and cluster two patients had different phenotypic features, possibly indicating different underlying genetic mechanisms. The cluster 1 phenotype may suggest a genetic or biology-based etiology, whereas the cluster two phenotype may be related to epigenetic mechanisms. Toxic exposure to cigarettes, either personally or secondarily, seems to be an important factor in the cluster two subgroup, inducing drug resistance and longer attacks. We need more studies to elaborate the causal relationship and the missing links of neurobiological pathways of cigarette smoking regarding the identified distinct phenotypic classes of patients with CH.
dc.description.issueMAY 20
dc.description.volume13
dc.identifier.doi10.3389/fneur.2022.898022
dc.identifier.urihttps://hdl.handle.net/11443/2609
dc.identifier.urihttp://dx.doi.org/10.3389/fneur.2022.898022
dc.identifier.wosWOS:000806499200001
dc.publisherFRONTIERS MEDIA SA
dc.relation.ispartofFRONTIERS IN NEUROLOGY
dc.subjectCluster Headache
dc.subjectcluster analysis
dc.subjectcigarette smoking
dc.subjecttobacco exposure
dc.subjecttrigeminal autonomic cephalagia
dc.subjectautonomic features
dc.titleCluster Analysis Revealed Two Hidden Phenotypes of Cluster Headache
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Cluster Analysis Revealed Two Hidden Phenotypes of Cluster Headache.pdf
Size:
519.7 KB
Format:
Adobe Portable Document Format

Collections