Long-term toxicity and survival outcomes after stereotactic ablative radiotherapy for patients with centrally located thoracic tumors

Sadeleştirilmiş öğe sayfası
dc.contributor.authorAtalar, Banu
dc.contributor.authorMustafayev, Teuta Zoto
dc.contributor.authorSio, Terence T.
dc.contributor.authorSahin, Bilgehan
dc.contributor.authorGungor, Gorkem
dc.contributor.authorAydin, Gokhan
dc.contributor.authorYapici, Bulent
dc.contributor.authorOzyar, Enis
dc.date.accessioned2023-02-21T12:36:42Z
dc.date.available2023-02-21T12:36:42Z
dc.date.issued2020-01-01
dc.description.abstractBackground. Stereotactic ablative radiotherapy (SABR) is effective for thoracic cancer and metastases
dc.description.abstracthowever, adverse effects are greater for central tumors. We evaluated factors affecting outcomes and toxicities after SABR for patients with primary lung and oligometastatic tumors. Patients and methods. We retrospectively identified consecutive patients with centrally located lung tumors that were treated at our hospital from 2009-2016. The effects of patient, disease, and treatment-related parameters on local control (LC), overall survival (OS), and toxicity-free survival (TFS) were evaluated with multivariate analyses. Results. Among 65 consecutive patients identified with 70 centrally located tumors, 20 tumors (28\%) were reirradiated. Median (range) total dose for all tumors was 55 (30-60) Gy in 5 (3-10) fractions. Radiographic complete response was obtained in 43 lesions (61\%). None of the analyzed factors were correlated with complete response. After a median follow-up of 57 (95\% CI, 48-65) months, 10 tumors (14\%) relapsed and 37 patients (57\%) died
dc.description.abstractthe actuarial 2- and 5-year OS rates were 52\% and 28\%, respectively. Median OS was significantly lower in patients with grade 3 or higher toxicity vs. lower toxicity (5 vs. 39 months
dc.description.abstractP < 0.001). Among 17 severe toxicities, 5 were grade 5, and 3 of them were reirradiated to the same field. Grade 3 to 5 TFS was lower with vs. without reirradiation (2-year TFS, 63\% vs. 96\%
dc.description.abstractP = 0.02). Conclusions. Our study showed that modern SABR is effective for central lung tumors, and toxicities are acceptable. SABR for reirradiated central lung lesions and possibly for lesions abutting the tracheobronchial tree may result in higher risk of serious toxicities.
dc.description.issue4
dc.description.issueDEC
dc.description.pages480-487
dc.description.volume54
dc.identifier.doi10.2478/raon-2020-0039
dc.identifier.urihttps://hdl.handle.net/11443/2138
dc.identifier.urihttp://dx.doi.org/10.2478/raon-2020-0039
dc.identifier.wosWOS:000604325400012
dc.publisherWALTER DE GRUYTER GMBH
dc.relation.ispartofRADIOLOGY AND ONCOLOGY
dc.subjectlung cancer
dc.subjectradiation
dc.subjectstereotactic ablative radiotherapy
dc.subjectstereotactic body radiation therapy
dc.subjectsurvival outcomes
dc.subjecttoxicity
dc.titleLong-term toxicity and survival outcomes after stereotactic ablative radiotherapy for patients with centrally located thoracic tumors
dc.typeArticle
Dosyalar
Koleksiyonlar
WOS