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Design and evaluation of innovative nanohybrids: porphyrin-loaded PEG-GO/AgNp systems for PDT

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dc.contributor.authorOnal, Emel
dc.contributor.authorKaplan, Ekrem
dc.contributor.authorTaylan, Gamze
dc.contributor.authorEmami, Atefeh
dc.contributor.authorBaykara, Tarik
dc.contributor.authorGurek, Ayse Gul
dc.date.accessioned2026-11-05T11:02:01Z
dc.date.issued2026
dc.description.abstractPEGylated graphene oxide (PEG-GO) and silver nanoparticles (AgNPs) were utilized to create hybrid nano-composite structures. Porphyrin was selected based on its substitution pattern, which is suitable for photodynamic therapy (PDT). An electron-withdrawing-NO2 group and an electron-donating-NH2 group were chosen as substituents on porphyrin to compare their effects on singlet oxygen generation. PEG-GO-Ag hybrid nano-composite structures with porphyrin were produced using the electrospinning method. The incorporation of Zn metal enhanced the spin-orbit coupling between the metal ion d-orbitals and the porphyrin it-system, potentially increasing singlet oxygen generation. Eight sets of hybrid nanocomposites were obtained. The singlet oxygen quantum yield values increased in the order from NO2 complexes to NH2 complexes. PEG-GO-Ag-Zn-Tetra/NH2 exhibited a singlet oxygen generation value of 0.59, the highest observed, indicating it as the most promising photosensitizer for improved photodynamic efficiency.
dc.description.pages115718
dc.description.sponsorshipWe are thankful to the Dogus , University Scientific Research Project (BAP) for financial support (project number: BAP-2019-2020-D1-B01) .
dc.description.volume183
dc.identifier.doi10.1016/j.inoche.2025.115718
dc.identifier.issn1387-7003
dc.identifier.issn1879-0259
dc.identifier.urihttps://doi.org/10.1016/j.inoche.2025.115718
dc.identifier.urihttps://openaccess.acibadem.edu.tr/handle/11443/10842
dc.identifier.wosWOS:001609606900001
dc.language.isoen
dc.publisherELSEVIER
dc.relation.fundingDogus University Scientific Research Project (BAP)(Dogus University)
dc.relation.fundingDogus University Scientific Research Project (BAP) [BAP-2019-2020-D1-B01]
dc.relation.hasversion10.1016/j.inoche.2025.115718
dc.relation.ispartofINORGANIC CHEMISTRY COMMUNICATIONS
dc.subjectPorphyrin
dc.subjectelectron donation
dc.subjectelectron withdrawing
dc.subjectPEG/GO
dc.subjectAg nanoparticle
dc.subjectSinglet oxygen generation
dc.subjectPHOTODYNAMIC THERAPY
dc.subjectSILVER NANOPARTICLES
dc.subjectNANO-GRAPHENE
dc.subjectNANOFIBERS
dc.subjectOXIDE
dc.subjectSUBSTITUENTS
dc.subjectPOLYMER
dc.subjectPD(II)
dc.subjectChemistry, Inorganic & Nuclear
dc.subjectChemistry
dc.titleDesign and evaluation of innovative nanohybrids: porphyrin-loaded PEG-GO/AgNp systems for PDT
dc.typeArticle
oaire.citation.editionScience Citation Index Expanded (SCI-EXPANDED)
oaire.citation.volume183
person.identifier.orcid0000-0002-2683-9539
person.identifier.orcid0000-0002-0298-2154
person.identifier.ridABG-1730-2021
person.identifier.ridAAG-5919-2019

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