Analysis of Mitochondrial DNA Control Region D-Loop in Gliomas: Result of 52 Patients
Analysis of Mitochondrial DNA Control Region D-Loop in Gliomas: Result of 52 Patients
Tarih
2021-01-01
Yazarlar
Yuksel, Sirin Kilicturgay
Ozduman, Koray
Yilmaz, Engin
Pamir, M. Necmettin
Akyerli, Cemaliye B.
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
Yayınevi
TURKISH NEUROSURGICAL SOC
Dergi Adı
TURKISH NEUROSURGERY
Özet
AIM: To investigate the effect of mitochondrial DNA (mtDNA) variants mainly in D-loop on glioma biology. MATERIAL and METHODS: Sanger sequencing of D-loop (15971-16451 bp) for 52 glioma patients was performed and the variations were statistically analyzed for gender, WHO classification, morphological grade, IDH/TERT status. RESULTS: Total of 122 variations (51 unique) were identified in 52 patients. C16223T, T16189C, T16311C and T16126C variants were frequently detected. The total variation number was statistically non-significant among the analyzed categories. When individual variants were considered, T16311C and T16224C were statistically significant for WHO classification (p=0.033), morphological grade (p=0.036) and gender (p=0.039), respectively. CONCLUSION: Total variation number in D-loop was not found to be related with clinical variables. Our data suggests that individual variants may play a critical role in glioma biology.
Açıklama
Anahtar kelimeler
D-loop, Glioma, Mitochondrial DNA, mtDNA variations, Mutations