Anti-neuronal and stress-induced-phosphoprotein 1 antibodies in neuro-Behcet's disease
Anti-neuronal and stress-induced-phosphoprotein 1 antibodies in neuro-Behcet's disease
Tarih
2011-01-01
Yazarlar
Vural, Burcak
Ugurel, Elif
Tuzun, Erdem
Kurtuncu, Murat
Zuliani, Luigi
Cavus, Filiz
Icoz, Sema
Erdag, Ece
Gul, Ahmet
Gure, Ali O.
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
Yayınevi
ELSEVIER SCIENCE BV
Dergi Adı
JOURNAL OF NEUROIMMUNOLOGY
Özet
No disease-specific neuronal antibodies have so far been defined in neuro-Behcet's disease (NBD). Immunohistochemistry and immunocytochemistry studies showed antibodies to hippocampal and cerebellar molecular layers and the surface antigens of cultured hippocampal neurons in sera and/or cerebrospinal fluids (CSF) of 13 of 20 NBD and 6 of 20 BD patients but not in multiple sclerosis or headache controls. Screening with a protein macroarray led to identification of stress-induced-phosphoprotein-1 (STIP-1) as an antigenic target. High-titer STIP-1-antibodies were detected in 6 NBD patients' sera but not in controls. These results suggest that neuronal antibodies could be useful as diagnostic biomarkers in NBD. (C) 2011 Elsevier B.V. All rights reserved.
Açıklama
Anahtar kelimeler
Behcet's disease, Neuro-Behcet's disease, Anti-neuronal antibody, Stress-induced-phosphoprotein 1, Antibody, Autoimmunity