Browsing by Author "Aydin, Ozlem"

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Human papillomavirus prevalence and type in liquid-based cervical samples from Turkish women in a selected risk group
(TUBITAK SCIENTIFIC \& TECHNICAL RESEARCH COUNCIL TURKEY, 2013-01-01) Akyar, Ism; Aydin, Ozlem; Yakicier, Mustafa Cengiz; Kocagoz, Zuhtu Taml; Ince, Umit; Unsal, Ibrahim
Aim: To detect the prevalence and type distribution of human papillomavirus (HPV) in different cytological diagnostic categories. Materials and methods: Between 2007 and 2010, a total of 1014 liquid-based thin preparations of cervical smears were selected and classified according to cytology results. HPV DNA polymerase chain reaction (PCR) was also performed using these samples. HPV DNA-positive samples were genotyped by DNA sequencing. Results: Of those enrolled in the study, 45.3\% were negative cytologically, 36.4\% had atypical squamous cells of undetermined significance, 0.3\% had atypical squamous cells preventing the exclusion of a high-grade squamous intraepithelial lesion, 16.8\% showed a low-grade squamous intraepithelial lesion, and 1.3\% had an high-grade squamous intraepithelial lesion. Conclusion: PCR assays showed HPV positivity in 63.0\% of cytologically negative and 90.8\% of cytologically positive samples. The most common types of HPV detected were 16, 6, 18, 31, 66, 56, 53, 81, 45, and 62. Of HPV DNA-positive samples, 47.7\% were high, 4.7\% were intermediate, and 17.9\% were low risk. The high-risk types of HPV detected were 16, 18, 31, 56, 53, 45, 62, 58, 59, 67, 51, 35, 73, 52, 33, 39, 68, and 82.
Lesion size determines diagnostic yield of EUS-FNA with onsite cytopathologic evaluation for upper gastrointestinal subepithelial lesions
(AVES, 2018-01-01) Attila, Tan; Aydin, Ozlem
Background/Aims: The aim of this study was to determine the diagnostic yield and factors influencing the diagnostic yield of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for upper gastrointestinal (GI) subepithelial lesions (SELs) with rapid onsite cytopathologic evaluation. Materials and Methods: This is a single-center, retrospective study. Results: Among 22 patients who underwent EUS-FNA, a cytopathological diagnosis was reached in 16 (72.7\%) patients. The EUS-FNA results were as follows: seven GISTS (31.8\%), six leiomyomas (27.2\%), four non-diagnostics (18\%), two duplication cysts (9\%), two spindle cell tumor (9\%), and one ectopic pancreas (4.5\%). The long-axis size was >20 mm in 12 patients (average size: 31.3 +/- 9.3 mm) and <20 mm (average size: 16.6 +/- 2.5 mm) in 10 patients. Diagnostic accuracy of EUS-FNA from lesions <20 mm was 50\% (5/10 lesions), and of lesions >20 mm was 91.6\% (11/12 lesions) (Fisher's exact test
Performance of the Bethesda System for Reporting Thyroid Cytology in Multi-Institutional Large Cohort of Pediatric Thyroid Nodules: A Detailed Analysis
(MDPI, 2022-01-01) Canberk, Sule; Barroca, Helena; Girao, Ines; Aydin, Ozlem; Uguz, Aysun; Erdogan, Kivilcim; Tastekin, Ebru; Bongiovanni, Massimo; Soares, Paula; Maximo, Valdemar; Schmitt, Fernando
Background: To evaluate the performance of TBSRTC through multi-institutional experience in the paediatric population and questioning the management recommendation of ATA Guidelines Task Force on Paediatric Thyroid Cancer
Primary Adrenal Lymphoma with Secondary Central Nervous System Involvement: A Case Report and Review of the Literature
(GALENOS YAYINCILIK, 2013-01-01) Aydin, Kubra; Okutur, Kerem; Bozkurt, Mustafa; Aydin, Ozlem; Namal, Esat; Ozturk, Akin; Pilanci, Kezban Nur; Kucukkaya, Reyhan Diz; Demir, Osman Gokhan
Approximately 10\%-20\% of all systemic lymphomas have central nervous system (CNS) involvement, which has been correlated to a worsened prognosis. It is well known that secondary involvement of the adrenal glands may occur in up to 25\% of patients during the course of diffuse lymphoma. Primary adrenal lymphoma (PAL), however, is a different entity, and it is defined as the presence of adrenal lymphoma without evidence of either nodal involvement or leukemia. It has been shown that this occurrence is rarely accompanied by extranodal involvement, such as in the CNS. PAL exhibits a tendency for CNS relapse and this possibility should be examined even before symptoms are present. Herein we present a patient with PAL and secondary CNS involvement.
What does the Data of 354,725 Patients from Turkey Tell Us About Cervical Smear Epithelial Cell Abnormalities? - The Epithelial Cell Abnormality Rate is Increasing - Quality Control Studies and Corrective Activity are Musts
(DE GRUYTER OPEN LTD, 2017-01-01) Turkmen, Ilknur Cetinaslan; Usubutun, Alp; Cakir, Asli; Aydin, Ozlem; Bolat, Filiz Aka; Akbulut, Metin; Altinay, Serdar; Arici, Sema; Aslan, Figen; Astarci, Muzeyyen; Bagir, Emine Kilic; Bas, Yilmaz; Bassullu, Nuray; Celik, Betul; Cetiner, Handan; Cobanoglu, Bengu; Aydin, Abdullah; Demir, Hale; Dogan, Hayriye Tatli; Eken, Kamile Gulcin; Erhan, Selma Sengiz; Erdogan, Gulgun; Erdogan, Kivilcim Eren; Eren, Funda; Ersoz, Safak; Firat, Pinar; Gurses, Iclal; Haberal, Nihan; Kahraman, Dudu Solakoglu; Kamali, Gulcin Harman; Karabulut, Yasemin Yuyucu; Kefeli, Mehmet; Koyuncuoglu, Meral; Koseoglu, R. Dogan; Muezzinoglu, Bahar; Onal, Binnur; Onder, Sevgen; Ozcan, Zuhal; Kimiloglu, Elife; Ozer, Hatice; Sonmez, F. Cavide; Sahin, Sevinc; Sahin, Nurhan; Yalta, Tulin
Objective: There is no other screening program close to the success rate of PAP test. Cervical cytology constitutes a large workload so that quality control in cervical cytology is important for the quality assurance of pathology laboratories. Material and Method: In this study, we collected the cervical cytology results from all over Turkey and discussed the parameters influencing the quality of the PAP test. The study was conducted with Turkish gynaecopathology working group and 38 centers (totally 45 hospitals) agreed to contribute from 24 different cities. The study was designed to cover the cervical cytology results during 2013. The results were evaluated from the data based on an online questionnaire. Results: The total number of Epithelial Cell Abnormality was 18,020 and the global Epithelial Cell Abnormality rate was 5.08\% in the total 354,725 smears and ranging between 0.3\% to 16.64\% among centers. The Atypical squamous cells/Squamous intraepithelial lesion ratios changed within the range of 0.21-13.94 with an average of 2.61. When the centers were asked whether they performed quality assurance studies, only 14 out of 28 centers, which shared the information, had such a control study and some quality parameters were better in these centers. Conclusion: There is an increase in the global Epithelial Cell Abnormality rate and there are great differences among centers. Quality control studies including the Atypical squamous cells/Squamous intraepithelial lesion ratio are important. Corrective and preventive action according to quality control parameters is a must. A cervical cytology subspecialist in every center can be utopic but a dedicated pathologist in the center is certainly needed.