Browsing by Author "Aydingoz, Ikbal Esen"

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Hepatitis C and hepatitis B virus infections in the etiopathogenesis of pemphigus
(SOC BRASILEIRA DERMATOLOGIA, 2014-01-01) Demirci, Gulsen Tukenmez; Aydingoz, Ikbal Esen; Mansur, Ayse Tulin; Atis, Guldehan; Altunay, Ilknur Kivanc
BACKGROUND: Previous studies have shown that some viral infections may be triggers for autoimmune diseases. The role of viral infections in the etiopathogenesis of pemphigus has also been investigated. OBJECTIVES: To investigate the relationship between pemphigus and the hepatitis B and C virus infections. METHODS: This retrospective study included 62 patients with pemphigus and 50 healthy controls of matching ages and genders. The control group included relatives who accompanied the orthopedic patients to the hospital but had no history of systemic and/or autoimmune diseases. RESULTS: The group of patients with pemphigus was composed of 43 (69.3\%) females and 19 (29.7\%) males, and the mean age was 48.08 +/- 15.38. The hepatitis C virus antibody was negative in all of the patients. Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb), or both, were studied in 44 of the 62 patients. Two (4.3\%) of these patients were positive for HBsAg and found to have HBV infection. Fourteen of them were HBsAb positive. Two (4\%) of the 50 control subjects showed hepatitis C virus antibody positivity, while only 1 (2\%) patient with pemphigus displayed HBsAg positivity. There was no statistically significant difference between the two groups for hepatitis B and C virus infections. CONCLUSIONS: This study does not support an association between pemphigus and hepatitis B and/or C virus infections.
Metabolic diseases with paraneoplastic features
(DERI ZUHREVI HASTALIKLAR DERNEGI, 2013-01-01) Aydingoz, Ikbal Esen; Akkaya, Ayse Deniz
Although metabolic diseases manifesting with cutaneous findings are rarely seen in daily practice, they emerge clinical significance as they can be the first manifestation of the systemic disease or can be seen in conjunction with other disorders. Among these diseases, scleromyxedema, diffuse normolipemic plane xanthoma, necrobiotic xanthogranuloma, amyloidosis and porphyria cutanea tarda can accompany myeloproliferative and lymphoproliferative diseases, as well as the malignancies of the solid organs. This paraneoplastic relationship can be diagnosed simultaneously at the time of the diagnosis of the cutaneous disease, or the cutaneous disease can precede the malignancy by several years. The recognition of these cutaneous diseases, appropriate screenings for the associated malignancies and the long term follow up of the patients can help to reduce the morbidity and mortality. Furthermore the treatment of the cutaneous disease can solely be possible with the management of the associated neoplasm.
Risk Factors in Pemphigus
(DERI ZUHREVI HASTALIKLAR DERNEGI, 2011-01-01) Demirci, Gulsen Tukenmez; Mansur, Ayse Tulin; Aydingoz, Ikbal Esen
Background and Design: There have been reports suggesting the involvement of environmental factors in the disease process of pemphigus. In this study, we aimed to find out the risk factors which could play role in the etiopathogenesis in our pemphigus patients. Material and method: A total of 42 patients (15 male and 27 female) who were diagnosed as pemphigus with histopathological and direct immunoflurosence examinations in our clinic between the years 1998-2004, were interviewed for assessment of regarding with the subjects of the demographic properties, occupational groups, educational level, the number of pregnancies, stressfull life events, diet habits, smoking and alcohol consumption before the onset of the disease and the results were compared to 42 age and gender-matched controls with similar socioeconomic circumstances. Results: Working in agriculture and livestock, multi-parity, absence of smoking and stressfull life events were found to be statistically significant in pemphigus patients than in controls. Conclusion: Working in agriculture and livestock, multi-parity, absence of smoking and stressfull life events were assumed to play role in the etiopathogenesis and course of pemphigus. (Turkderm 2011
The Evaluation of Endothelin-1 and Endothelin Receptor Type A Gene Polymorphisms in Patients with Vitiligo
(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2016-01-01) Bingul, Ilknur; Aydingoz, Ikbal Esen; Vural, Pervin; Dogru-Abbasoglu, Semra; Uysal, Mujdat
Background: Endothelin-1 (EDNi) and EDN receptor type A (EDNRA) are implicated in melanocyte functions. Aim and Objectives: This study examines the role of EDN1 (G5665T and T-1370G) and EDNRA (C + 70G and G-231A) polymorphisms as a risk factor for vitiligo, and evaluates the relationship between genotypes and clinical characteristics of vitiligo patients. Materials and Methods: We analyzed genotype/alele distributions of EDN1 and EDNRA polymorphisms in 100 patients with vitiligo and 185 healthy controls by real-time polymerase chain reaction. Results: There was no notable risk for vitiligo afflicted by studied polymorphisms. However, the presence of EDNRA + 70 variant G allele was found to be related with decreased risk for development of generalized type of vitiligo (odds ratio {[}OR]: 0.42, 95\% confidence interval {[}CI] = 0.21-0.86, Por = 0.03) and showed protective effect against associated diseases seen in vitiligo (OR: 0.49, 95\% CI = 0.27-0.88, p(corr) = 0.034). Haplotype analysis demonstrated a strong (disequilibrium coefficient = 0.73, r(2) = 0.405) linkage disequilibrium between EDN1 G5665T and T-1370G polymorphisms. The EDN1 5665/-1330 TT haplotype was over represented significantly in controls than in patients (P = 0.04). Conclusion: The studied polymorphisms do not seem to be a major risk for vitiligo. Haplotype analysis denoting protective effects against vitiligo may indicate an indirect interaction in the course of vitiligo. In addition, EDNRA + 70 polymorphism is protective against generalized type of vitiligo and associated diseases.