Browsing by Author "Aygun, Elif Ganime"

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Effects of Normal Morphology Sperm Count on Fertilization Time in Infertile Couples with Teratospermic Males: An Evaluation with an Embryoscope
(GALENOS YAYINCILIK, 2022-01-01) Aygun, Elif Ganime; Karabuk, Emine
Objective: Incubation of the embryo is the vital step in assisted reproductive techniques. Embryoscope systems are incubators that keep the embryo stable and allow for continuous observation without opening the lid. Therefore, the embryo is not displaced and goes through a temperature or air change. The primary aim of this study was to explore the effects of normal morphology sperm count on two pronucleus formation time following intracytoplasmic sperm injection in infertile couples with teratospermic males. The secondary aim was clinical pregnancy. Materials and Methods: Sixty-seven couples undergoing in vitro fertilization were included in this retrospective cohort study. First, intracytoplasmic sperm injection was performed to metaphase II-oocytes. Then, the embryos were placed in an embryoscope (a time-lapse system) for observation. The time that embryos demonstrated two pronuclei were recorded. Demographic and reproductive data were obtained and analyzed. Results: A statistically significant weak correlation was detected between sperm morphology the two pronucleus formation times (r=0.295, p=0.017). Severely decreased normal sperm count was significantly associated with pregnancy with less decreased normal sperm count (p>0.024). Moreover, decreased two pronucleus formation time was significantly associated with pregnancy. Conclusion: A statistically significant, albeit weak, correlation was detected between sperm morphology with two pronucleus formation time. Furthermore, having a lower normal sperm count was related to a higher pregnancy rate than having a higher normal sperm count. Lastly, reduced two pronucleus formation time was significantly associated with pregnancy.
Effects of stem cells and amniotic fluid on uterus and ovaries in a rat model of abdominal adhesions: a controlled study
(GALENOS PUBL HOUSE, 2022-01-01) Aygun, Elif Ganime; Tumentemur, Gamze
Objective: This study aimed to compare the effects of human umbilical cord mesenchymal stem cells (hUCMSCs), amniotic fluid (AF), and a combination of both on the uterus and ovaries in a rat model of abdominal adhesions.Material and Methods: This study was designed as a controlled study. Four groups, each consisting of six rats, were randomly formed. One group was designated as the control (CNT). hUCMSCs -applied (hUCSC), AF-applied (AMN), and a combination of both (hUCSC + AMN) were the experimental groups. All rats were given intraperitoneal talc powder to create adhesions. After 21 days, animals in experimental groups were further treated with hUCMSC, AF or a combination of these.Results: There was a statistically significant difference in primordial follicle count, endometrial gland number, and endometrial blood vessel count (p<0.05). AMN provided the best results in the endometrial vessel and primordial follicle count. The average endometrial gland count in AMN and hUCSC + AMN was similarly higher than CNT and hUCSC alone.Conclusion: There were significantly higher for counts for endometrial glands, endometrial blood vessels, and primordial follicles in the hUCSC, AMN and hUCSC + AMN groups compared to controls. Animals in the AMN group had the best result for endometrial vessel and highest primordial follicle count. (J Turk Ger Gynecol Assoc 2022
Labor Induction with Intravaginal Misoprostol versus Spontaneous Labor: Maternal and Neonatal Outcomes
(HINDAWI LTD, 2022-01-01) Ozbasli, Esra; Canturk, Melis; Aygun, Elif Ganime; Ozaltin, Selin; Gungor, Mete
Purpose. To compare the maternal and neonatal outcomes of pregnant women who had labor induction with intravaginal misoprostol or had spontaneous labor in our clinic. Material-Method. The records of 213 pregnant women, who were followed up in Acibadem Maslak University Hospital for vaginal delivery between June 2021 and December 2021, were retrospectively evaluated. The pregnant women, who gave birth, were divided into 3 groups as follows: spontaneous labor (SL), those induced by a single dose of misoprostol (SDM), and those induced by multiple doses of misoprostol (MDM). The groups were compared in terms of delivery type, the vaginal birth rate within 12 hours, need for intervention, duration of the second stage of labor, cesarean section ratio due to fetal distress, time from the last dose to delivery, and 1st and 5th minute APGAR scores. Results. Among the primiparous pregnant women, 84.7\% of SL group, 65.2\% of SDM group, and 37\% MDM group delivered vaginally within 12 hours (p < 0.05). The time from the last misoprostol dose to delivery was also statistically significantly shorter in pregnant women, who received a single dose of misoprostol (483 vs. 720 min, respectively). When the hospitalization time was evaluated, in the SDM group, the MDM group, and the SL group, it was found to be 611, 831, and 379 min, respectively. In multiparous pregnant women, the hospitalization time was 735 min in the SDM group, 494 min in the MDM group, and 261.5 min in the SL group (p < 0.05). Other than the hospitalization time, when the aforementioned variables were studied in multiparous pregnant women, no statistically significant difference among groups was observed (p > 0.05). Conclusion. Intravaginal misoprostol seems to be a promising medical agent for labor induction due to its high delivery rates within 12 hours and the absence of negative fetal outcomes, its ease of storage, and affordable cost.
Marsupialization versus Word catheter in the treatment of Bartholin cyst or abscess: retrospective cohort study
(GALENOS PUBL HOUSE, 2022-01-01) Karabuk, Emine; Aygun, Elif Ganime
Objective: Bartholin cysts or abscesses are observed in approximately 2\% of women, usually in their reproductive years. Although none of the treatments appear to be superior, there are several options including drainage with basic incision, Word catheter application, marsupialization, silver nitrate application, and excision. The primary outcome in this study was to evaluate the recurrence rates in patients who underwent marsupialization or Word catheter for the treatment of Bartholin cyst or abscesses, and the secondary outcome was to evaluate the rates of patient satisfaction. Material and Methods: A total of 196 patients who underwent either Word catheterization or marsupialization for the treatment of Bartholin cyst or abscesses between 2014 and 2017 were included in this retrospective cohort study. The size and location of the cyst/abscess, the operation duration, and the recurrence was recorded. A 5-point visual analog scale (VAS) was used to assess patient satisfaction and whether patients would recommend thier treatment to others. Results: Recurrence was observed in 11 (8.3\%) patients in the marsupialization group, and 12 (18.8\%) patients in the Word catheter group (p=0.034). Median (range) VAS scores in the marsupialization group were better than the Word catheter group {[}4 (1-5) vs 3 (1-5)